Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.
Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.
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HTLV-1 和粪类圆线虫合并感染患者的类圆线虫病治疗与 TNFα 增加和可溶性 IL2 受体水平降低相关。
DOI：
10.1093/trstmh/trt052
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发表时间：
2013
影响因子：
2.2
通讯作者：
Carvalho,Edgar
中科院分区：
文献类型：
--
作者：
Salles,Fernanda;Bacellar,Andrea;Amorim,Mirla;Orge,Glória;Sundberg,Michael;Lima,Márcia;Santos,Silvane;Porto,Aurélia;Carvalho,Edgar
背景人类T细胞嗜淋巴细胞病毒1型（HTLV-1）感染与复发性和播散性类圆线虫病以及成人T细胞白血病/淋巴瘤（ATLL）有关。并评估粪类圆线虫治疗对HTLV免疫应答和临床结局的影响。结果HTLV-1和S.仅HTLV-1患者的排粪作用显著降低（p < 0.05），驱虫治疗后TNFα水平升高。HTLV-1与S.驱虫剂和粪石治疗可降低sIL-2 R水平（P < 0.05）。1例发生ATLL的患者同时感染了S.结论蠕虫感染对HTLV-1感染有调节作用，S.粪尿可能是ATLL发生的辅助因素。
BackgroundHuman T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).MethodsWe compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence ofStrongyloides stercoralistreatment on the immune response and clinical outcomes of HTLV-1 infection.ResultsLevels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 andS. stercoralisthan in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected withS. stercoralisand anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected withS. stercoralis.ConclusionThese data show that helminthic infection has a modulatory role in HTLV-1 infection and thatS. stercoralismay be a cofactor in the development of ATLL.
影响因子：
23.4
作者：
Temml, C;Heidler, S;Madersbacher, S
通讯作者：
Madersbacher, S
DOI：
10.1086/427560
发表时间：
2005-02
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
A. Porto;S. Santos;A. Muniz;Vanessa Basilio;W. Rodrigues;F. Neva;W. Dutra;K. Gollob;S. Jacobson;E. Carvalho
通讯作者：
A. Porto;S. Santos;A. Muniz;Vanessa Basilio;W. Rodrigues;F. Neva;W. Dutra;K. Gollob;S. Jacobson;E. Carvalho
DOI：
10.1016/s1201-9712(02)90132-3
发表时间：
2002-03-01
影响因子：
8.4
作者：
Terashima, Angelica;Alvarez, Humberto;Gotuzzo, Eduardo
通讯作者：
Gotuzzo, Eduardo