HLA-DP antigens are involved in the susceptibility to multiple sclerosis.
HLA-DP antigens are involved in the susceptibility to multiple sclerosis.
复制标题
HLA-DP 抗原与多发性硬化症的易感性有关。
DOI：
10.1111/j.1399-0039.1988.tb02088.x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
A. Svejgaard
中科院分区：
文献类型：
--
作者：
N. Ødum;J. J. Hyldig;N. Morling;M. Sandberg;P. Platz;A. Svejgaard
采用引物淋巴细胞分型技术对45例瑞典多发性硬化症（MS）患者和166例丹麦对照患者进行HLA-DP分型。用限制性片段长度多态性（RFLP）技术对39例ms患者和63例对照者进行HLA-DP和-DR基因的dna分型。DPw4的频率在MS患者中为93.3%，对照组为72.3%（相对危险度，RR = 5.4, p = 0.0014）。75.5%的患者和33.7%的对照组存在DR2抗原（RR = 6.1, p < 10(-6)）。在患者或对照组中，DPw4与DR2不相关（即不存在连锁不平衡）。因此，在多发性硬化症中，与DP和DR的关联是相互独立的。然而，DPw4和DR2联合存在的风险明显高于单独存在的风险，这表明DP和DR基因产物之间的协同作用可能在MS的遗传易感性中起作用。
Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.
少关节型幼年类风湿性关节炎患者的 HLA-DP 抗原。
影响因子：
--
作者：
Hoffman,RW;Shaw,S;Francis,LC;Larson,MG;Petersen,RA;Chylack,LT;Glass,DN
通讯作者：
Glass,DN