TRPC Channels and Parkinson's Disease.
TRPC Channels and Parkinson's Disease.
复制标题
DOI：
10.1007/978-94-024-1088-4_8
复制
发表时间：
2017
影响因子：
--
通讯作者：
Singh BB
中科院分区：
文献类型：
--
作者：
Sukumaran P;Sun Y;Schaar A;Selvaraj S;Singh BB
帕金森病（Parkinson disease，PD）是一种常见的神经退行性疾病，主要累及黑质（substantia nigra pars rectata，SNpc）区的多巴胺能神经元。许多因素已被确定可能导致帕金森病，但几乎所有这些因素都直接或间接依赖于Ca2+信号。重要的是，尽管帕金森病和其他神经元疾病涉及钙稳态的紊乱，但钙通道的身份仍然难以捉摸。瞬时受体电位经典（TRPC）通道家族成员已被鉴定为一类新的钙通道，并且可以预期这些通道在神经退行性疾病，特别是在PD中可能发挥重要作用。因此，在本章中，我们完全集中我们的注意力在TRPC通道和阐明其在PD中的作用。
Parkinson disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson disease, however almost all of them are directly or indirectly dependent on Ca2+ signaling. Importantly, though disturbances in Ca2+ homeostasis have been implicated in Parkinson’s disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of calcium channels and it could be anticipated that these channels could play a major role in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused our attention on TRPC channels and elucidating its role in PD.
登录
查看更多内容
影响因子：
4
作者：
Huang, W.-C.;Young, J. S.;Glitsch, M. D.
通讯作者：
Glitsch, M. D.
DOI：
10.1073/pnas.0810599106
发表时间：
2009-04-21
影响因子：
11.1
作者：
Becker, Esther B. E.;Olivera, Peter L.;Davies, Kay E.
通讯作者：
Davies, Kay E.
线粒体DNA多态性的鉴定会改变线粒体基质pH和细胞内钙动力学。
影响因子：
4.5
作者：
Kazuno, An-a;Munakata, Kae;Nagai, Takeharu;Shimozono, Satoshi;Tanaka, Masashi;Yoneda, Makoto;Kato, Nobumasa;Miyawaki, Atsushi;Kato, Tadafumi
通讯作者：
Kato, Tadafumi
影响因子：
4.8
作者：
Jayadev, S;Petranka, JG;Murphy, E
通讯作者：
Murphy, E
影响因子：
4.8
作者：
Bollimuntha, S;Singh, BB;Ebadi, M
通讯作者：
Ebadi, M