Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches.
Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches.
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先兆子痫：新的机制和潜在的治疗方法。
DOI：
10.3389/fphys.2018.00973
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发表时间：
2018
影响因子：
4
通讯作者：
Abassi ZA
中科院分区：
文献类型：
--
作者：
Armaly Z;Jadaon JE;Jabbour A;Abassi ZA
先兆子痫是一种严重的妊娠并发症，它影响所有妊娠的5-8%。它增加了胎儿和孕妇的发病率和死亡率，特别是在发展中国家。它严重影响几个重要器官，包括肾脏、肝脏、大脑和肺。虽然，先兆子痫的发病机制尚未完全理解，越来越多的证据表明，血管生成因子水平和凝血功能障碍的异常是负责疾病的临床表现。所有这些靶器官的组织损伤的共同命名者是内皮损伤，其阻碍了它们的正常功能。在肾脏水平，肾小球内皮损伤导致母体蛋白尿的发生。事实上，继发于母体全身炎症和内皮细胞活化的外周血管收缩足以发展为先兆子痫诱导的高血压。类似地，先兆子痫可由于血管损伤和/或高血压而引起肝脏和神经功能障碍。显然，先兆子痫对各个器官产生不利影响，但目前尚不清楚先兆子痫本身是否对各个器官产生不利影响，或者它是否暴露了在以后生活中表现出的心血管疾病的潜在遗传易感性。本文综述了子痫前期发病机制的最新进展，特别关注新的诊断生物标志物及其与这种疾病状态的潜在治疗选择的相关性。具体而言，审查强调了肾脏表现的疾病与血管损伤的血管生成因子的参与，以及如何恢复血管生成的平衡影响肾脏和心血管的先兆子痫妇女的结果。
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidneys, liver, brain, and lung. Although, the pathogenesis of preeclampsia has not yet been fully understood, growing evidence suggests that aberrations in the angiogenic factors levels and coagulopathy are responsible for the clinical manifestations of the disease. The common nominator of tissue damage of all these target organs is endothelial injury, which impedes their normal function. At the renal level, glomerular endothelial injury leads to the development of maternal proteinuria. Actually, peripheral vasoconstriction secondary to maternal systemic inflammation and endothelial cell activation is sufficient for the development of preeclampsia-induced hypertension. Similarly, preeclampsia can cause hepatic and neurologic dysfunction due to vascular damage and/or hypertension. Obviously, preeclampsia adversely affects various organs, however it is not yet clear whether pre-eclampsia per se adversely affects various organs or whether it exposes underlying genetic predispositions to cardiovascular disease that manifest in later life. The current review summarizes recent development in the pathogenesis of preeclampsia with special focus on novel diagnostic biomarkers and their relevance to potential therapeutic options for this disease state. Specifically, the review highlights the renal manifestations of the disease with emphasis on the involvement of angiogenic factors in vascular injury and on how restoration of the angiogenic balance affects renal and cardiovascular outcome of Preeclamptic women.
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DOI：
10.4021/jocmr1682w
发表时间：
2014-02
期刊：
Journal of clinical medicine research
影响因子：
--
作者：
Al-Jameil N;Aziz Khan F;Fareed Khan M;Tabassum H
通讯作者：
Tabassum H
影响因子：
3.8
作者：
Cindrova-Davies, T.
通讯作者：
Cindrova-Davies, T.
影响因子：
10.8
作者：
Cindrova-Davies T;Sanders DA;Burton GJ;Charnock-Jones DS
通讯作者：
Charnock-Jones DS
DOI：
10.1111/j.1471-0528.1992.tb14409.x
发表时间：
1992-10-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
BENIGNI, A;ORISIO, S;REMUZZI, G
通讯作者：
REMUZZI, G
影响因子：
20.1
作者：
Ahmad, S;Ahmed, A
通讯作者：
Ahmed, A