Novel left ventricular mechanical index in pulmonary arterial hypertension.
Novel left ventricular mechanical index in pulmonary arterial hypertension.
复制标题
DOI：
10.1002/pul2.12216
复制
发表时间：
2023-04
影响因子：
2.6
通讯作者：
Haddad, Francois
中科院分区：
文献类型：
--
作者：
Ichimura, Kenzo;Santana, Everton J.;Kuznetsova, Tatiana;Cauwenberghs, Nicholas;Sabovcik, Frantisek;Chun, Lindsey;Francisco, Nadia L. C.;Kheyfets, Vitaly O.;Salerno, Michael;Zamanian, Roham T.;Spiekerkoetter, Edda;Haddad, Francois
心室相互依赖性在肺动脉高压（PAH）中起重要作用。它可以降低左心室（LV）纵向应变（LVLS），并导致室间隔（sTS）的横向位移（“横向缩短”）。在本研究中，我们假设LVLS/sTS比值是PAH中收缩期心室相互作用的敏感标志物。在PAH患者（n = 57）和匹配对照（n = 57）的横断面队列中，我们在振幅和时域中定量了LVLS和间隔TS。然后，我们在一个有代表性的45例患者的队列中，使用扰乱图、心室相互作用网络分析和纵向分析来表征LV表型。我们还在基线、PAB后第1周和第7周（N = 9）使用7 T磁共振成像测量了接受肺动脉束带（PAB）的小鼠的LV指标。与对照组相比，PAH患者的绝对LVLS显著降低（15.4 ± 3.4 vs. 20.1 ± 2.3%，p < 0.0001），sTS升高（53.0 ± 12.2 vs. 28.0 ± 6.2%，p < 0.0001），LVLS/sTS降低（0.30 ± 0.09 vs. 0.75 ± 0.16，p < 0.0001）。在89.5%的患者中观察到LVLS/sTS降低，而分别在73.7%、52.6%和15.8%的患者中观察到舒张功能障碍、LVLS受损（<16%）和LV萎缩。在纵向队列中，LVLS/sTS的变化与N末端前B型利钠肽的变化（r = 0.73，p < 0.0001）以及生存率密切相关。与假手术动物相比，接受PAB的小鼠显示出显著的RV收缩功能障碍和LVLS/sTS降低。我们的结论是，在PAH中，LVLV/sTS是一个简单的比率，可以反映心室收缩的相互作用。
Ventricular interdependence plays an important role in pulmonary arterial hypertension (PAH). It can decrease left ventricular (LV) longitudinal strain (LVLS) and lead to a leftward displacement (“transverse shortening”) of the interventricular septum (sTS). For this study, we hypothesized the ratio of LVLS/sTS would be a sensitive marker of systolic ventricular interactions in PAH. In a cross‐sectional cohort of patients with PAH (n = 57) and matched controls (n = 57), we quantified LVLS and septal TS in the amplitude and time domain. We then characterized LV phenotypes using upset plots, ventricular interactions using network analysis, and longitudinal analysis in a representative cohort of 45 patients. We also measured LV metrics in mice subjected to pulmonary arterial banding (PAB) using a 7 T magnetic resonance imaging at baseline, Week 1, and Week 7 post‐PAB (N = 9). Patients with PAH had significantly reduced absolute LVLS (15.4 ± 3.4 vs. 20.1 ± 2.3%, p < 0.0001), higher sTS (53.0 ± 12.2 vs. 28.0 ± 6.2%, p < 0.0001) and lower LVLS/sTS (0.30 ± 0.09 vs. 0.75 ± 0.16, p < 0.0001) compared to controls. Reduced LVLS/sTS was observed in 89.5% of patients, while diastolic dysfunction, impaired LVLS (<16%), and LV atrophy were observed in 73.7%, 52.6%, and 15.8%, respectively. In the longitudinal cohort, changes in LVLS/sTS were closely associated with changes in N‐terminal pro B‐type natriuretic peptide (r = 0.73, p < 0.0001) as well as survival. Mice subjected to PAB showed significant RV systolic dysfunction and decreased LVLS/sTS compared to sham animals. We conclude that in PAH, LVLV/sTS is a simple ratio that can reflect ventricular systolic interactions.
登录
查看更多内容
DOI：
10.1109/tvcg.2014.2346248
发表时间：
2014-12
影响因子：
5.2
作者：
Lex A;Gehlenborg N;Strobelt H;Vuillemot R;Pfister H
通讯作者：
Pfister H
DOI：
10.1016/j.echo.2015.05.002
发表时间：
2015-07-01
影响因子：
6.5
作者：
Marwick, Thomas H.;Gillebert, Thierry C.;Zamorano, Jose L.
通讯作者：
Zamorano, Jose L.
影响因子：
37.8
作者：
BRINKER, JA;WEISS, JL;WEISFELDT, ML
通讯作者：
WEISFELDT, ML
影响因子：
2.4
作者：
Dell'Italia, Louis J.
通讯作者：
Dell'Italia, Louis J.
影响因子：
2.8
作者：
Ghio, S;Recusani, F;Tavazzi, L
通讯作者：
Tavazzi, L