Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.
Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.
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DOI：
10.3390/ijms24065378
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发表时间：
2023-03-11
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性疼痛影响着世界各地的许多人，而且这个数字还在不断增加。通过激活交感神经系统，慢性疼痛与心血管疾病的发展之间存在明显的联系。这篇综述的目的是从文献中提供证据，强调交感神经系统功能障碍与慢性疼痛之间的直接关系。我们假设，在慢性疼痛的背景下，调节交感神经系统和疼痛感知的共同神经网络中的不良适应变化有助于交感神经过度激活和心血管疾病。我们回顾了临床证据，并强调了连接交感网络和伤害性网络的基本神经回路以及控制这两者的神经网络之间的重叠。
Chronic pain affects many people world-wide, and this number is continuously increasing. There is a clear link between chronic pain and the development of cardiovascular disease through activation of the sympathetic nervous system. The purpose of this review is to provide evidence from the literature that highlights the direct relationship between sympathetic nervous system dysfunction and chronic pain. We hypothesize that maladaptive changes within a common neural network regulating the sympathetic nervous system and pain perception contribute to sympathetic overactivation and cardiovascular disease in the setting of chronic pain. We review clinical evidence and highlight the basic neurocircuitry linking the sympathetic and nociceptive networks and the overlap between the neural networks controlling the two.
影响因子：
3.6
作者：
Parsons, S.;McBeth, J.;Macfarlane, G. J.;Hannaford, P. C.;Symmons, D. P. M.
通讯作者：
Symmons, D. P. M.