Self-reported pain severity is associated with a history of coronary heart disease.
Self-reported pain severity is associated with a history of coronary heart disease.
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DOI：
10.1002/ejp.533
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发表时间：
2015-02
影响因子：
3.6
通讯作者：
Symmons, D. P. M.
中科院分区：
文献类型：
--
作者：
Parsons, S.;McBeth, J.;Macfarlane, G. J.;Hannaford, P. C.;Symmons, D. P. M.
先前的研究发现慢性疼痛与心血管（CV）死亡率之间存在关联。探索疼痛严重程度与非致死性CV疾病之间的关系。从曼彻斯特和阿伯丁的全科诊所登记册中随机选择的45，994名成年人进行了一项调查，其中包括慢性疼痛等级问卷，疼痛模型以及有关生活方式和病史的问题。使用因子分析提取测量疼痛严重程度的单个组分。使用逻辑回归分析来检验疼痛严重程度的五分位数与CV疾病史之间的相关性，调整混杂因素。在15，288名应答者中，61%（n = 9357）在过去一个月内报告疼痛≥ 1天。与第一（最低）疼痛严重程度五分位数相比，第二严重程度五分位数中心脏病发作的完全校正比值比为1.25（95%置信区间0.68，2.30）;第三个五分位数：1.65（0.93，2.94）;第四个五分位数：1.76（1.00，3.11）和第五个（最高）五分位数2.47（1.43，4.28）。心绞痛（不包括心脏病发作）的相应数字分别为：1.79（0.93，3.45）、1.91（1.00，3.62）、1.03（0.50，2.11）和3.17（1.71，5.85）。严重疼痛患者中CV疾病史的报告频率高于偶然预期，即使调整了共同的风险因素。
Previous studies have found an association between chronic pain and cardiovascular (CV) mortality. To explore the relationship between the severity of pain and non-fatal CV disease. A total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders. Of the 15,288 responders, 61% (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95% confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85). A history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.
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