Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model.
Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model.
复制标题
补充牛磺酸可减少铁超载小鼠模型中的氧化应激并保护肝脏
DOI：
10.3892/mmr.2014.2544
复制
发表时间：
2014-11
影响因子：
3.4
通讯作者：
He M
中科院分区：
文献类型：
--
作者：
Zhang Z;Liu D;Yi B;Liao Z;Tang L;Yin D;He M
我们先前的研究表明，铁超载可通过产生活性氧物种(ROS)来导致肝脏损伤。牛磺酸是一种强有力的自由基清除剂，可以减轻过量氧自由基造成的损害。因此，本研究的目的是探讨牛磺酸是否能从ROS的产生方面减轻铁超载对肝脏的毒性。小鼠每周5天连续13周腹腔注射铁，以达到铁超载。研究发现，铁超载会导致肝功能障碍、细胞凋亡增加和氧化应激增加。补充牛磺酸可使肝脏牛磺酸水平增加40%，改善肝功能，减少细胞凋亡、ROS形成和线粒体肿胀，减轻线粒体膜电位的损失。牛磺酸治疗可减轻铁超载小鼠的氧化应激，减轻肝脏脂质过氧化，提高抗氧化酶活性，并维持降低的谷胱甘肽水平。这些结果表明，牛磺酸可减轻铁诱导的肝脏氧化应激，保护肝功能，抑制肝细胞凋亡。因此，牛磺酸可能是一种潜在的治疗药物，可减轻铁超载所致的肝损伤。
We previously demonstrated that iron overload induces liver damage by causing the formation of reactive oxygen species (ROS). Taurine is a potent free radical scavenger that attenuates the damage caused by excessive oxygen free radicals. Therefore, the aim of the present study was to investigate whether taurine could reduce the hepatotoxicity of iron overload with regard to ROS production. Mice were intraperitoneally injected with iron 5 days/week for 13 weeks to achieve iron overload. It was found that iron overload resulted in liver dysfunction, increased apoptosis and elevated oxidative stress. Taurine supplementation increased liver taurine levels by 40% and led to improved liver function, as well as a reduction in apoptosis, ROS formation and mitochondrial swelling and an attenuation in the loss of the mitochondrial membrane potential. Treatment with taurine mediated a reduction in oxidative stress in iron-overloaded mice, attenuated liver lipid peroxidation, elevated antioxidant enzyme activities and maintained reduced glutathione levels. These results indicate that taurine reduces iron-induced hepatic oxidative stress, preserves liver function and inhibits hepatocyte apoptosis. Therefore, taurine may be a potential therapeutic drug to reduce liver damage caused by iron overload.
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影响因子：
1.2
作者：
Hayashi, Hisao;Piperno, Alberto;Goto, Hidemi
通讯作者：
Goto, Hidemi
DOI：
10.2478/10004-1254-64-2013-2297
发表时间：
2013-06-01
影响因子：
2.1
作者：
Heidari, Reza;Babaei, Hossein;Eghbal, Mohammad Ali
通讯作者：
Eghbal, Mohammad Ali
影响因子：
3.3
作者：
Liu, C. -M.;Zheng, G. H.;Cheng, C.
通讯作者：
Cheng, C.
影响因子：
9.3
作者：
Liao, Yingjun;Lu, Xiuqiang;Tang, Hao
通讯作者：
Tang, Hao
影响因子：
4.5
作者：
GALLEANO, M;PUNTARULO, S
通讯作者：
PUNTARULO, S