Anatomy and physiology of principal cells of the medial nucleus of the trapezoid body (MNTB) of the cat.
Anatomy and physiology of principal cells of the medial nucleus of the trapezoid body (MNTB) of the cat.
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猫梯形体（MNTB）内侧核主要细胞的解剖学和生理学。
DOI：
10.1152/jn.1998.79.6.3127
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发表时间：
1998
影响因子：
2.5
通讯作者：
Yin,TC
中科院分区：
文献类型：
--
作者：
Smith,PH;Joris,PX;Yin,TC
Smith, Philip H., Philip X. Joris, 和 Tom C. T. Yin.猫梯形体内侧核 (MNTB) 主要细胞的解剖学和生理学。 NeuroPhysol.79: 3127–3142, 1998。我们使用装有神经生物素或辣根过氧化物酶的玻璃微移液器记录猫上橄榄复合体的梯形体内侧核（MNTB）的主要细胞，进行细胞内记录和随后的标记，或依赖于预电势和电极位置的细胞外金属微电极。标记的主细胞具有通常产生一两个初级树突的细胞体，这些初级树突在细胞附近大量分支。在电子显微镜（EM）水平上，细胞体和近端树突上有密集的突触末端分布。多达一半的测量细胞表面可能被兴奋性末端覆盖，而抑制性末端始终覆盖约五分之一。远端树突的神经支配非常稀疏。粗有髓轴突起源于细胞体，并仅在同侧听觉脑干中受神经支配的核团。这些包括外侧上橄榄核 (LSO)、外侧丘系的腹侧核、内侧上橄榄核、背内侧和腹内侧橄榄周核以及 MNTB 本身。在 EM 水平上，有髓鞘的侧支产生包含非圆形囊泡的末端，并且在 LSO 中，观察到终止于细胞体和初级树突。 MNTB 细胞的反应在很多方面与其主要兴奋性输入球状丛状细胞 (GBC) 相似。特征频率（CF）低的 MNTB 细胞的自发峰值率较低，而 CF 单位较高的 MNTB 细胞的自发峰值率往往较高。在响应短音时，低频 MNTB 细胞相对于听觉神经纤维表现出增强的锁相能力。对于 CF > 1 kHz 的细胞，短音响应通常类似于许多球状浓密细胞中看到的初级样陷波响应，具有适时的起始分量。还指出了该标准响应的例外情况和变化。与具有可比 CF 的 GBC 相比，MNTB 细胞反应的潜伏期略有延迟，正如预期的那样，考虑到两种细胞类型之间插入了突触。因此，我们的数据证实，在猫中，MNTB 接收来自球状丛状细胞的突触输入并将其转换为相当准确的丛状细胞尖峰反应再现。这种 MNTB 细胞输出随后成为许多同侧听觉脑干核的重要抑制输入。
Smith, Philip H., Philip X. Joris, and Tom C. T. Yin.Anatomy and physiology of principal cells of the medial nucleus of the trapezoid body (MNTB) of the cat.J. Neurophysiol.79: 3127–3142, 1998. We have recorded from principal cells of the medial nucleus of the trapezoid body (MNTB) in the cat's superior olivary complex using either glass micropipettes filled with Neurobiotin or horseradish peroxidase for intracellular recording and subsequent labeling or extracellular metal microelectrodes relying on prepotentials and electrode location. Labeled principal cells had cell bodies that usually gave rise to one or two primary dendrites, which branched profusely in the vicinity of the cell. At the electron microscopic (EM) level, there was a dense synaptic terminal distribution on the cell body and proximal dendrites. Up to half the measured cell surface could be covered with excitatory terminals, whereas inhibitory terminals consistently covered about one-fifth. The distal dendrites were very sparsely innervated. The thick myelinated axon originated from the cell body and innervated nuclei exclusively in the ipsilateral auditory brain stem. These include the lateral superior olive (LSO), ventral nucleus of the lateral lemniscus, medial superior olive, dorsomedial and ventromedial periolivary nuclei, and the MNTB itself. At the EM level the myelinated collaterals gave rise to terminals that contained nonround vesicles and, in the LSO, were seen terminating on cell bodies and primary dendrites. Responses of MNTB cells were similar to their primary excitatory input, the globular bushy cell (GBC), in a number of ways. The spontaneous spike rate of MNTB cells with low characteristic frequencies (CFs) was low, whereas it tended to be higher for higher CF units. In response to short tones, a low frequency MNTB cell showed enhanced phase-locking abilities, relative to auditory nerve fibers. For cells with CFs >1 kHz, the short tone response often resembled the primary-like with notch response seen in many globular bushy cells, with a well-timed onset component. Exceptions to and variations of this standard response were also noted. When compared with GBCs with comparable CFs, the latency of the MNTB cell response was delayed slightly, as would be expected given the synapse interposed between the two cell types. Our data thus confirm that, in the cat, the MNTB receives and converts synaptic inputs from globular bushy cells into a reasonably accurate reproduction of the bushy cell spike response. This MNTB cell output then becomes an important inhibitory input to a number of ipsilateral auditory brain stem nuclei.
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DOI：
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