Differences in case-fatality-rate of emerging SARS-CoV-2 variants.
Differences in case-fatality-rate of emerging SARS-CoV-2 variants.
复制标题
DOI：
10.1016/j.puhip.2022.100350
复制
发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
He D
中科院分区：
文献类型：
--
作者：
Liu J;Wei H;He D
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的变异体在全球范围内造成了巨大的影响。据广泛报道，Omicron（B.1.1.529）变体的致命性低于Delta（B.1.617.2）变体，可能是由于疫苗接种和既往感染的免疫力。当测量变异的严重程度时，通常估计病死率（CFR）。这项工作的目的是计算自2020年大流行开始以来，大量国家╱地区不同变种的病死率随时间的变化。横断面研究。我们将比较扩展到58个县/地区的所有以前的VOC。我们使用报告的死亡除以30天滑动窗口中报告的病例，报告的死亡和报告的病例之间有两周的变化。从Delta变体到Omicron变体的下降幅度很大，Omicron的亚变体之间的差异不明显。我们发现CFR随着时间的推移而下降，可能是由于疫苗诱导的免疫和感染诱导的免疫。人口年龄结构和合并症的患病率影响CFR。
Variants of Severe-Acute-Respiratory-Syndrome Coronavirus-2 (SARS-CoV-2) has caused tremendous impact globally. It has been widely reported that the Omicron (B.1.1.529) variant is less deadly than the Delta (B.1.617.2) variant, presumably due to immunity from vaccination and previous infection. When measuring the severity of a variant, Case-Fatality-Rate (CFR) is often estimated. The purpose of this work is to calculate the change in CFR of different variants over time from a large number of countries/regions since the start of the pandemic in 2020. A Cross-sectional study. We extend the comparison to all previous VOCs in 58 counties/regions. We use reported death divided by reported cases in 30-day sliding window with a two-week shift between reported death and reported cases. The drop from Delta variant to Omicron variant is substantial and the difference between subvariants of Omicron is not evident. We showed that the CFR dropped over time, presumably due to vaccine-induced immune and infection induced immune. Population age structure and prevalence of comorbidity influence CFR.
登录
查看更多内容
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
33.9
作者：
Johnson, Amelia G.;Amin, Avnika B.;Ali, Akilah R.;Hoots, Brooke;Cadwell, Betsy L.;Arora, Shivani;Avoundjian, Tigran;Awofeso, Abiola O.;Barnes, Jason;Bayoumi, Nagla S.;Busen, Katherine;Chang, Carolyn;Cima, Mike;Crockett, Molly;Cronquist, Alicia;Davidson, Sherri;Davis, Elizabeth;Delgadillo, Janelle;Dorabawila, Vajeera;Drenzek, Cherie;Eisenstein, Leah;Fast, Hannah E.;Gent, Ashley;Hand, Julie;Hoefer, Dina;Holtzman, Corinne;Jara, Amanda;Jones, Amanda;Kamal-Ahmed, Ishrat;Kangas, Sarah;Kanishka, F. N. U.;Kaur, Ramandeep;Khan, Saadiah;King, Justice;Kirkendall, Samantha;Klioueva, Anna;Kocharian, Anna;Kwon, Frances Y.;Logan, Jacqueline;Lyons, B. Casey;Lyons, Shelby;May, Andrea;McCormick, Donald;Mendoza, Erica;Milroy, Lauren;O'Donnell, Allison;Pike, Melissa;Pogosjans, Sargis;Saupe, Amy;Sell, Jessica;Smith, Elizabeth;Sosin, Daniel M.;Stanislawski, Emma;Steele, Molly K.;Stephenson, Meagan;Stout, Allen;Strand, Kyle;Tilakaratne, Buddhi P.;Turner, Kathryn;Vest, Hailey;Warner, Sydni;Wiedeman, Caleb;Zaldivar, Allison;Silk, Benjamin J.;Scobie, Heather M.
通讯作者：
Scobie, Heather M.
估计Omicron和Delta Sars-Cov-2感染的疾病严重程度。
DOI：
10.1038/s41577-022-00720-5
发表时间：
2022-05
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
SARS-CoV-2 Delta 和非 Delta 变种相关病死风险与疫苗覆盖率的差异：英国的一项早期生态研究
DOI：
10.1016/j.meegid.2021.105162
发表时间：
2022-01
期刊：
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子：
--
作者：
Zhao S;Lou J;Cao L;Chong KC;Zee BCY;Chan PKS;Wang MH
通讯作者：
Wang MH