The effect of offspring number on the adaptation speed of a polygenic trait
The effect of offspring number on the adaptation speed of a polygenic trait
复制标题
后代数量对多基因性状适应速度的影响
DOI：
10.1101/212613
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Pfenninger M
中科院分区：
文献类型：
--
作者：
Pfenninger M
越来越多的证据表明，数量性状的快速表型适应在自然界中并不罕见。然而，多基因性状的快速适应发生的情况还不清楚。本文在前人软选择理论的基础上，提出并验证了多基因性状的适应速度取决于随机交配二倍体群体中每对育种对的后代数的假设，并对不同规模群体中每对亲本的后代数范围（2-200）进行了个体建模（100-10000个体），我可以证明，到目前为止，最大比例的方差（42%）是由后代数量解释的，而不管遗传性状结构（10-50个位点，不同的位点贡献分布）。此外，它可以确定大多数的责任基因座，并解释更多的观察到的表型变化与适度的群体大小。模拟结果表明，后代的数量可能是一个关键因素的适应速度的数量基因座。此外，由于大量的后代数量转化为每个亲本对后代的大表型方差，这种遗传赌注对冲策略增加了在不可预测的环境中为下一代做出贡献的机会。“因此，当生产出来的个体多于可能生存的个体时，在任何情况下都必须有生存的斗争，或者是一个个体与同一物种的另一个个体，或者是与不同物种的个体，或者是与生命的物质条件。（达尔文，1859年，第三章）
There is increasing evidence that rapid phenotypic adaptation of quantitative traits is not uncommon in nature. However, the circumstances under which rapid adaptation of polygenic traits occurs are not yet understood. Building on previous concepts of soft selection, i.e. frequency and density dependent selection, I developed and tested the hypothesis that adaptation speed of a polygenic trait depends on the number of offspring per breeding pair in a randomly mating diploid population.Using individual based modelling on a range of offspring per parent (2–200) in populations of various size (100–10000 individuals), I could show that the by far largest proportion of variance (42%) was explained by the offspring number, regardless of genetic trait architecture (10–50 loci, different locus contribution distributions). In addition, it was possible to identify the majority of the responsible loci and account for even more of the observed phenotypic change with a moderate population size.The simulation results suggest that offspring numbers may a crucial factor for the adaptation speed of quantitative loci. Moreover, as large offspring numbers translates to a large phenotypic variance in the offspring of each parental pair, this genetic bet hedging strategy increases the chance to contribute to the next generation in unpredictable environments.“Hence, as more individuals are produced than can possibly survive, there must in every case be a struggle for existence, either one individual with another of the same species, or with the individuals of distinct species, or with the physical conditions of life.”(Darwin, 1859, chapter III)
影响因子：
3.3
作者：
WALLACE, B
通讯作者：
WALLACE, B
基于并行遗传算法的数量性状分析变量选择方法
影响因子：
1.9
作者：
Mukhopadhyay,Siuli;George,Varghese;Xu,Hongyan
通讯作者：
Xu,Hongyan