Combinative analysis of factors influence serum alanine aminotransferase activity in adult male population from southern China.
Combinative analysis of factors influence serum alanine aminotransferase activity in adult male population from southern China.
复制标题
我国南方成年男性血清谷丙转氨酶活性影响因素的组合分析
DOI：
10.1016/j.clinbiochem.2012.08.022
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发表时间：
2012-12
影响因子：
2.8
通讯作者：
彭涛
中科院分区：
文献类型：
--
作者：
彭涛
OBJECTIVESAbnormal alanine aminotransferase (ALT) activity is indicative of liver disease even a burden of overall health. We assessed the factors associated with ALT activity and their internal relationships in a male population from southern China.DESIGN AND METHODSData of physical examinations, laboratory tests, hepatic ultrasounds and standardized questionnaire were collected from 2119 males participating in a population-based survey from September 2009 to December 2009.RESULTSNonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) were associated with the elevation of ALT levels (P<0.05). Prevalence of NAFLD was correlated to MetS (r=0.991, P=0.009). The levels of abnormal metabolic syndrome components increased in proportion with the ALT elevation (P<0.01). Obesity and hyperlipidemia were associated with the ALT levels in multivariate regression analysis (P<0.01). There was no synergic effect of hepatitis B virus surface antigen (HBsAg) and MetS on the ALT levels (synergy index [SI]=0.74, 95% confidence interval [CI]: 0.71–0.80).CONCLUSIONNAFLD and MetS were associated with ALT levels in a male population from southern China. Obesity and hyperlipidemia were independent MetS components contributing to elevated ALT (e-ALT). This finding might suggest necessity on justification of these confounding factors when detecting ALT levels among this population.
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影响因子：
29.4
作者：
Fraser, Abigail;Longnecker, Matthew P.;Lawlor, Debbie A.
通讯作者：
Lawlor, Debbie A.
影响因子：
3.7
作者：
Dong MH;Bettencourt R;Barrett-Connor E;Loomba R
通讯作者：
Loomba R
影响因子：
9.8
作者：
D. Sorbi;J. Boynton;K. Lindor
通讯作者：
D. Sorbi;J. Boynton;K. Lindor
DOI：
10.1111/j.1440-1746.2006.04615.x
发表时间：
2007-09-01
影响因子：
4.1
作者：
Chen, Chien-Hua;Huang, Min-Ho;Yueh, Sen-Kou
通讯作者：
Yueh, Sen-Kou
影响因子：
105.7
作者：
SAVERYMUTTU, SH;JOSEPH, AEA;MAXWELL, JD
通讯作者：
MAXWELL, JD