Tobacco Use Disorder.

Tobacco Use Disorder.
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DOI:
10.1016/j.mcna.2021.08.011
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发表时间:
2022-01
期刊:
The Medical clinics of North America
影响因子:
--
通讯作者:
Evers-Casey S
Evers-Casey S
中科院分区:
其他
文献类型:
--
作者:
Leone FT;Evers-Casey S

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烟草使用障碍非常普遍,全世界有超过10亿人使用烟草。关于烟草成瘾潜力的流行观点往往低估了支持其持续使用的复杂神经适应。虽然尼古丁有时被认为是一种“次要”物质,但它对行为的影响在一生的接触中总是会导致严重的疾病。烟草加工的创新导致了烟草的有效形式,以及最大限度地提高尼古丁增强能力的输送装置。最近,出现了积极主动的治疗策略,重点是药物治疗干预来解决烟草使用障碍。即将到来的创新为帮助临床医生以更适合表型的方式解决这一问题带来了巨大的希望。然而,需要努力防止后代吸烟。
Tobacco use disorder is highly prevalent and over a billion individuals use tobacco worldwide. Popular views on the addictive potential of tobacco often underestimate the complex neural adaptations that underpin its continued use. While sometimes trivialized as a “minor” substance, the effects of nicotine on behavior invariably lead to profound morbidity over a lifetime of exposure. Innovations in tobacco processing have led to potent forms of tobacco, and delivery devices that maximize the reinforcing capacity of nicotine. Most recently, proactive treatment strategies have emerged that focus on pharmacotherapeutic interventions to address tobacco use disorder. Innovations on the horizon hold significant promise for helping clinicians address this problem in a more phenotypically-tailored manner. However, efforts will be needed to prevent use of tobacco for future generations.
DOI: 10.1007/bf02245429
发表时间: 1992-03-01
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影响因子: 3.4
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