Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
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DOI：
10.1177/2045893217717219
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发表时间：
2017-07
影响因子：
2.6
通讯作者：
Dweik RA
中科院分区：
文献类型：
--
作者：
Tonelli AR;Fares WH;Dakkak W;Rao Y;Zhou X;Dweik RA
瘦素（一种神经内分泌肽，可增强代谢并作用于下丘脑以抑制食欲）和脂联素（一种具有胰岛素增敏、抗炎和抗增殖特性的蛋白质）参与肺动脉高压（PAH）的病理生物学。我们假设PAH患者血浆瘦素和脂联素以及瘦素/脂联素比值异常，其水平随随访期间疾病严重程度和功能变化而变化。我们在16周、国际、多中心、双盲、安慰剂对照的FREEDOM-C2研究中纳入的患者队列中检验了这一假设。在基线和第16周时采集了310例随机化PAH患者中178例的血液。基线血浆瘦素和脂联素浓度分别为25 ± 31 ng/mL和7.8 ± 6.1 ug/mL。16周时瘦素、脂联素和瘦素/脂联素（平均值± SD）的变化幅度较小。基线时的瘦素与年龄较大、BMI较高、博格呼吸困难指数较高和NT-pro BNP较低显著相关。女性的瘦素水平高于男性（30.5 ± 33.2ng/mL vs 7.2 ± 6.4ng/mL），即使调整了背景治疗和病因（线性回归：β = 21.8，P < 0.001）。脂联素与BMI呈负相关，与NT-pro BNP呈正相关。在16周时，瘦素、脂联素和瘦素/脂联素比值的变化并不能预测功能分级、6分钟步行距离或1年、2年、3年或4年的生存率。血浆瘦素和脂联素在基线水平及其在16周时的变化似乎对PAH的预后无显著影响。
Leptin (a neuroendocrine peptide that enhances metabolism and acts on the hypothalamus to suppress appetite) and adiponectin (a protein that has insulin-sensitizing, anti-inflammatory, and antiproliferative properties) are involved in the pathobiology of pulmonary arterial hypertension (PAH). We hypothesized that plasma leptin and adiponectin as well as the leptin/adiponectin ratio are abnormal in PAH patients and their levels track with disease severity and functional changes during follow-up. We tested this hypothesis in a cohort of patients included in the 16-week, international, multicenter, double-blind, placebo-controlled FREEDOM-C2 study. Blood was collected at baseline and week 16 in 178 out of 310 randomized patients with PAH. Baseline plasma leptin and adiponectin concentrations were 25 ± 31 ng/mL and 7.8 ± 6.1 ug/mL, respectively. Leptin, adiponectin, and leptin/adiponectin (mean ± SD) changes at 16 week were of small magnitude. Leptin at baseline was significantly associated with older age, higher BMI, higher Borg dyspnea index, and lower NT-pro BNP. Women had higher levels of leptin than men (30.5 ± 33.2 versus 7.2 ± 6.4 ng/mL), even when adjusting for background therapy and etiology (linear regression: β = 21.8, P < 0.001). Adiponectin was negatively associated with BMI and positively associated with NT-pro BNP. Changes in leptin, adiponectin, and leptin/adiponectin ratio adjusted for weight at 16 weeks did not predict functional class, distance walk in 6 min or survival at one, two, three, or four years. Plasma leptin and adiponectin at baseline and their change at 16-week do not appear to significantly impact prognosis in PAH.
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影响因子：
2.6
作者：
Tonelli, Adriano R;Aytekin, Metin;Dweik, Raed A
通讯作者：
Dweik, Raed A
影响因子：
5.8
作者：
Fain, JN;Kanu, A;Hiler, ML
通讯作者：
Hiler, ML
DOI：
10.1165/rcmb.2008-0415oc
发表时间：
2009-10-01
影响因子：
6.4
作者：
Medoff, Benjamin D.;Okamoto, Yoshihisa;Luster, Andrew D.
通讯作者：
Luster, Andrew D.
影响因子：
24.3
作者：
Huertas, Alice;Tu, Ly;Guignabert, Christophe
通讯作者：
Guignabert, Christophe
影响因子：
9.6
作者：
Tapson, Victor F.;Jing, Zhi-Cheng;Rubin, Lewis J.
通讯作者：
Rubin, Lewis J.