The macrophage at the intersection of immunity and metabolism in obesity.
The macrophage at the intersection of immunity and metabolism in obesity.
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DOI：
10.1186/1758-5996-3-29
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发表时间：
2011-10-28
影响因子：
4.8
通讯作者：
Samaan MC
中科院分区：
文献类型：
--
作者：
Samaan MC
肥胖是一种全球性流行病，是全球社会面临的主要挑战之一。确定其发展和传播所涉及的机制将有助于制定预防和治疗策略，从而有助于控制其上升率。肥胖与慢性低度炎症有关，这被认为是导致胰岛素抵抗的主要原因之一，胰岛素抵抗是肥胖的早期事件，当胰腺无法跟上胰岛素需求增加时，就会导致 2 型糖尿病。在这篇综述中，我们讨论了巨噬细胞在介导肥胖代谢器官（包括脂肪组织、骨骼肌和肝脏）炎症中的作用。与代谢器官界面处免疫细胞的存在调节这些器官的代谢功能和炎症反应，并可能提供调节肥胖代谢功能的潜在治疗靶点。
Obesity is a worldwide pandemic representing one of the major challenges that societies face around the globe. Identifying the mechanisms involved in its development and propagation will help the development of preventative and therapeutic strategies that may help control its rising rates. Obesity is associated with chronic low-grade inflammation, and this is believed to be one of the major contributors to the development of insulin resistance, which is an early event in obesity and leads to type 2 diabetes when the pancreas fails to keep up with increased demand for insulin. In this review, we discuss the role of macrophages in mediation of inflammation in obesity in metabolic organs including adipose tissue, skeletal muscle and liver. The presence of immune cells at the interface with metabolic organs modulates both metabolic function and inflammatory responses in these organs, and may provide a potential therapeutic target to modulate metabolic function in obesity.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
5.8
作者：
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影响因子：
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作者：
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DOI：
10.1016/j.bbadis.2009.08.007
发表时间：
2009-11
影响因子：
6.2
作者：
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通讯作者：
Mooney, Robert A.
影响因子：
2.9
作者：
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通讯作者：
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