Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke.
Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke.
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DOI：
10.1155/2017/8526438
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发表时间：
2017
影响因子：
--
通讯作者：
Hung YC
中科院分区：
文献类型：
--
作者：
Cheng YC;Sheen JM;Hu WL;Hung YC
良好的营养可以维持健康和生命。多酚是常见的营养素，主要来自水果、蔬菜、茶、咖啡、可可、蘑菇、饮料和传统草药。它们是对抗氧化相关疾病的潜在物质，例如，心血管疾病，特别是动脉粥样硬化相关的缺血性心脏病和中风，这些是世界范围内公认的健康和经济问题。本文综述了动脉粥样硬化的危险因素，包括高血压、糖尿病、高脂血症、肥胖和吸烟，以及多酚类物质的抗氧化活性，它可以预防动脉粥样硬化的病理过程，包括内皮功能障碍、低密度脂蛋白氧化、血管平滑肌细胞增殖、单核细胞、巨噬细胞或T淋巴细胞的炎症过程以及血小板聚集。多酚类物质具有较强的自由基清除能力，具有抗氧化和抗炎作用。多酚通过抑制氧化酶、减少超氧化物的产生、抑制OxLDL形成、抑制VSMC增殖和迁移、减少血小板聚集和改善线粒体氧化应激来减少ROS产生。多酚的消耗也抑制高血压、糖尿病、高脂血症和肥胖症的发展。尽管有许多体内和体外研究，但需要更先进的临床试验来证实多酚在治疗动脉粥样硬化相关血管疾病中的功效。
Good nutrition could maintain health and life. Polyphenols are common nutrient mainly derived from fruits, vegetables, tea, coffee, cocoa, mushrooms, beverages, and traditional medicinal herbs. They are potential substances against oxidative-related diseases, for example, cardiovascular disease, specifically, atherosclerosis-related ischemic heart disease and stroke, which are health and economic problems recognized worldwide. In this study, we reviewed the risk factors for atherosclerosis, including hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette smoking as well as the antioxidative activity of polyphenols, which could prevent the pathology of atherosclerosis, including endothelial dysfunction, low-density lipoprotein oxidation, vascular smooth muscle cell proliferation, inflammatory process by monocytes, macrophages or T lymphocytes, and platelet aggregation. The strong radical-scavenging properties of polyphenols would exhibit antioxidative and anti-inflammation effects. Polyphenols reduce ROS production by inhibiting oxidases, reducing the production of superoxide, inhibiting OxLDL formation, suppressing VSMC proliferation and migration, reducing platelet aggregation, and improving mitochondrial oxidative stress. Polyphenol consumption also inhibits the development of hypertension, diabetes mellitus, hyperlipidemia, and obesity. Despite the numerous in vivo and in vitro studies, more advanced clinical trials are necessary to confirm the efficacy of polyphenols in the treatment of atherosclerosis-related vascular diseases.
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影响因子：
2
作者：
Ashigai, Hiroshi;Taniguchi, Yoshimasa;Fukuhara, Ikuo
通讯作者：
Fukuhara, Ikuo
影响因子：
3.6
作者：
Broekhuizen, Lysette N.;van Wijk, Diederik F.;Stroes, Erik S. G.
通讯作者：
Stroes, Erik S. G.
影响因子：
5
作者：
Chen, Jing-Hsien;Lee, Ming-Shih;Lin, Hui-Hsuan
通讯作者：
Lin, Hui-Hsuan
DOI：
10.1016/j.bbalip.2016.06.020
发表时间：
2017-04
期刊：
Biochimica et biophysica acta. Molecular and cell biology of lipids
影响因子：
--
作者：
Choi SH;Sviridov D;Miller YI
通讯作者：
Miller YI
影响因子：
5.1
作者：
Chen, HW;Chien, ML;Wang, TS
通讯作者：
Wang, TS