Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.
Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.
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DOI：
10.3389/fnagi.2022.1085989
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
阿尔茨海默病（Alzheimer's disease，AD）是一种进行性神经退行性疾病。然而，AD的早期过程尚未完全了解，并且可能在症状出现前开始年就开始了。重要的是，包括海马在内的默认模式网络的破坏与AD有关。为了研究功能网络连接变化在AD早期阶段的作用，我们使用携带三种家族性AD突变（AppNL-G-F/NL-G-F敲入，APPKI）的小鼠模型在早期、中期和晚期年龄组的雌性小鼠中进行静息态功能磁共振成像（rs-fMRI）。海马的半球间和半球内的功能连接（FC）是跨年龄建模。我们观察到更高的半球间功能连接（FC）在不同年龄的海马。然而，在APPKI小鼠中，这种情况在以后的年龄中有所减少。此外，我们还观察到APPKI小鼠FC半球不对称性的丧失。总之，这表明在β淀粉样蛋白斑块严重发作之前，海马FC存在早期变化，并且其可能作为AD的早期生物标志物具有临床相关性。
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The early processes of AD, however, are not fully understood and likely begin years before symptoms manifest. Importantly, disruption of the default mode network, including the hippocampus, has been implicated in AD. To examine the role of functional network connectivity changes in the early stages of AD, we performed resting-state functional magnetic resonance imaging (rs-fMRI) using a mouse model harboring three familial AD mutations (AppNL-G-F/NL-G-F knock-in, APPKI) in female mice in early, middle, and late age groups. The interhemispheric and intrahemispheric functional connectivity (FC) of the hippocampus was modeled across age. We observed higher interhemispheric functional connectivity (FC) in the hippocampus across age. This was reduced, however, in APPKI mice in later age. Further, we observed loss of hemispheric asymmetry in FC in APPKI mice. Together, this suggests that there are early changes in hippocampal FC prior to heavy onset of amyloid β plaques, and which may be clinically relevant as an early biomarker of AD.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
64.8
作者：
Harris CR;Millman KJ;van der Walt SJ;Gommers R;Virtanen P;Cournapeau D;Wieser E;Taylor J;Berg S;Smith NJ;Kern R;Picus M;Hoyer S;van Kerkwijk MH;Brett M;Haldane A;Del Río JF;Wiebe M;Peterson P;Gérard-Marchant P;Sheppard K;Reddy T;Weckesser W;Abbasi H;Gohlke C;Oliphant TE
通讯作者：
Oliphant TE
影响因子：
3.7
作者：
Cruchaga C;Haller G;Chakraverty S;Mayo K;Vallania FL;Mitra RD;Faber K;Williamson J;Bird T;Diaz-Arrastia R;Foroud TM;Boeve BF;Graff-Radford NR;St Jean P;Lawson M;Ehm MG;Mayeux R;Goate AM;NIA-LOAD/NCRAD Family Study Consortium
通讯作者：
NIA-LOAD/NCRAD Family Study Consortium
影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V