Kinetics of transcription of human cytomegalovirus chemokine receptor US28 in different cell types.

Kinetics of transcription of human cytomegalovirus chemokine receptor US28 in different cell types.
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不同细胞类型中人巨细胞病毒趋化因子受体 US28 的转录动力学。

DOI:
10.1099/0022-1317-80-3-543
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发表时间:
1999
期刊:
The Journal of general virology
影响因子:
--
通讯作者:
S. Michelson
S. Michelson
中科院分区:
--
文献类型:
--
作者:
D. Zipeto;B. Bodaghi;L. Laurent;J. Virelizier;S. Michelson

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在允许细胞中,人巨细胞病毒编码蛋白US 28,一种功能性CC趋化因子受体。RT-PCR可在感染后2 h检测到US 28多聚腺苷酸化mRNA。US 28 mRNA出现在主要IE 1转录物(UL 123)之后,但在早期基因pp 65(UL 83)和gB(UL 55)以及晚期基因pp 150(UL 32)的转录物之前。这种时间上的出现表明US 28的转录比以前报道的要早。此外,US 28 mRNA可在半和非允许细胞中检测到。
In permissive cells, human cytomegalovirus encodes the protein US28, a functional CC chemokine receptor. US28 polyadenylated mRNA could be detected by RT-PCR as early as 2 h post-infection. US28 mRNA appeared after major IE1 transcripts (UL123), but before transcripts of the early genes pp65 (UL83) and gB (UL55), and the late gene pp150 (UL32). This temporal appearance indicates that US28 is transcribed earlier than previously reported. Furthermore, US28 mRNA could be detected in semi- and non-permissive cells.
DOI: 10.1093/infdis/169.4.769
发表时间: 1994-04-01
影响因子: 6.4
作者:
FRIES, BC;CHOU, SW;TOROKSTORB, B
通讯作者: TOROKSTORB, B