Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study.
Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study.
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DOI：
10.3390/bioengineering9070326
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发表时间：
2022-07-18
影响因子：
4.6
通讯作者：
Yang, Zifeng
中科院分区：
文献类型：
--
作者：
Yi, Hang;Johnson, Mark;Bramlage, Luke C.;Ludwig, Bryan;Yang, Zifeng
脑动脉系统中的脉动流率（PFR）和分叉动脉中的分流比是两个可能影响脑动脉瘤病理生物学中血流动力学特征的患者特异性参数，需要全面识别。因此，采用系统的研究来研究脉动流率（即，PFR−I、PFR−II和PFR−III）和分流比（即，75：25和64：36），以及使用计算流体动力学（CFD）建模的两个颈内动脉侧壁动脉瘤模型中血液动力学模式的瞬时心脏脉动波形。数值结果表明，较大的PFR可能会在颅内圆顶的某些局部区域引起较高的壁面剪切应力（），与较小的PFR相比，这可能会增加小型/继发性动脉瘤的发生概率。在较小的PFR下，可能出现低和相对高的振荡剪切指数（），增加了囊肿生长和破裂的潜在风险。然而，PFR和分叉分流比的变化对囊上的时间平均压力分布（）的影响很小，尽管由于重定向血流的冲击相对较强，较高的PFR可能对ICASA-1圆顶中的压力增加的贡献大于ICASA-2。CFD模拟还表明，分叉远端动脉的分流比的变化对囊中的血流动力学特性的影响很少，主要是因为在目前的模型中分叉位置不够接近囊。此外，它已被发现，涡流的位置起着重要的作用，在时间和空间分布的WSS上的管腔壁，随心动周期显着变化。
The pulsatile flow rate (PFR) in the cerebral artery system and shunt ratios in bifurcated arteries are two patient-specific parameters that may affect the hemodynamic characteristics in the pathobiology of cerebral aneurysms, which needs to be identified comprehensively. Accordingly, a systematic study was employed to study the effects of pulsatile flow rate (i.e., PFR−I, PFR−II, and PFR−III) and shunt ratio (i.e., 75:25 and 64:36) in bifurcated distal arteries, and transient cardiac pulsatile waveform on hemodynamic patterns in two internal carotid artery sidewall aneurysm models using computational fluid dynamics (CFD) modeling. Numerical results indicate that larger PFRs can cause higher wall shear stress () in some local regions of the aneurysmal dome that may increase the probability of small/secondary aneurysm generation than under smaller PFRs. The low and relatively high oscillatory shear index () could appear under a smaller PFR, increasing the potential risk of aneurysmal sac growth and rupture. However, the variances in PFRs and bifurcated shunt ratios have rare impacts on the time-average pressure () distributions on the aneurysmal sac, although a higher PFR can contribute more to the pressure increase in the ICASA−1 dome due to the relatively stronger impingement by the redirected bloodstream than in ICASA−2. CFD simulations also show that the variances of shunt ratios in bifurcated distal arteries have rare impacts on the hemodynamic characteristics in the sacs, mainly because the bifurcated location is not close enough to the sac in present models. Furthermore, it has been found that the vortex location plays a major role in the temporal and spatial distribution of the WSS on the luminal wall, varying significantly with the cardiac period.
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影响因子：
1.6
作者：
Byoun HS;Huh W;Oh CW;Bang JS;Hwang G;Kwon OK
通讯作者：
Kwon OK
影响因子：
1.8
作者：
Fennell VS;Kalani MY;Atwal G;Martirosyan NL;Spetzler RF
通讯作者：
Spetzler RF
DOI：
10.1002/cnm.3111
发表时间：
2018-09
影响因子：
2.1
作者：
Botti L;Paliwal N;Conti P;Antiga L;Meng H
通讯作者：
Meng H
影响因子：
4.8
作者：
Cebral, Juan R.;Vazquez, Mariano;Putman, Christopher M.
通讯作者：
Putman, Christopher M.
影响因子：
8.3
作者：
Kaminogo, M;Yonekura, M;Shibata, S
通讯作者：
Shibata, S