Prognostic significance of estrogen receptors in 405 primary breast cancers: a comparison of immunohistochemical and biochemical methods
Prognostic significance of estrogen receptors in 405 primary breast cancers: a comparison of immunohistochemical and biochemical methods
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雌激素受体在 405 例原发性乳腺癌中的预后意义：免疫组化和生化方法的比较
DOI：
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发表时间：
1997
影响因子：
3.8
通讯作者：
G. Cetto
中科院分区：
文献类型：
--
作者：
A. Molino;R. Micciolo;M. Turazza;F. Bonetti;Q. Piubello;A. Corgnati;L. Sperotto;E. Recaldin;R. Spagnolli;E. Manfrin;A. Bonetti;R. Nortilli;G. Pollini;S. Modena;G. Cetto
在过去的几年中，通过免疫组织化学方法测定雌激素受体已得到广泛应用。本研究的目的是将该技术与通过葡聚糖包被木炭测定雌激素受体进行比较，并评估这两种方法中的一种是否更能预测预后。采用右旋糖酐包被炭法和免疫组织化学方法测定405例原发性乳腺癌患者的雌激素受体；还记录了年龄、病理肿瘤大小、淋巴结状态和葡聚糖涂层木炭法测定的孕激素受体。采用乘积极限法估计无病生存率和总生存率； Cox比例风险模型用于评估两种方法测定的雌激素受体的预后作用。两种方法测定的雌激素受体之间似乎存在密切关联（一致结果的81.5%），并且它们的预后作用相似，即使将患者分为不同的组（根据其雌激素受体状态）并且考虑到其他预后变量的影响的调整也是如此。我们的研究表明，这两种方法可以无差异地用于评估雌激素受体状态作为乳腺癌患者的预后因素。
Over the last few years, estrogen receptor determinationby means of immunohistochemistry has been extensively used.The aim of this study was to comparethis technique with estrogen receptor determination by meansof dextran-coated charcoal, and to evaluate whether oneof the two methods is more predictive ofprognosis. Estrogen receptors were determined by means ofboth the dextran-coated charcoal method and immunohistochemistry in405 patients with primary breast cancer; age, pathologicaltumor size, nodal status, and progesteron receptors bydextran-coated charcoal method were also recorded. The disease-freeand overall survival probabilities were estimated using theproduct-limit method; Cox's proportional hazard model was usedto evaluate the prognostic role of estrogen receptorsas determined by the two methods.There appears to be a close association betweenestrogen receptor determination by the two methods (81.5%of concordant results) and their prognostic role wassimilar, even when the patients were divided intodifferent groups (on the basis of their estrogenreceptor status) and adjustments for the effect ofother prognostic variables were taken into account. Ourstudy shows that the two methods can beused indifferently to evaluate estrogen receptor status asa prognostic factor in breast cancer patients.
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影响因子：
4
作者：
G. Clark;W. McGuire
通讯作者：
G. Clark;W. McGuire
DOI：
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发表时间：
1972
期刊：
--
影响因子：
--
作者：
D. Cox
通讯作者：
D. Cox
影响因子：
11.2
作者：
L. B. Kinsel;E. Szabo;G. Greene;J. Konrath;G. Leight;K. Mccarty
通讯作者：
L. B. Kinsel;E. Szabo;G. Greene;J. Konrath;G. Leight;K. Mccarty
雌激素受体免疫细胞化学测定对人类乳腺癌的预后有用性。
影响因子：
11.2
作者：
DeSombre,ER;Thorpe,SM;Rose,C;Blough,RR;Andersen,KW;Rasmussen,BB;King,WJ
通讯作者：
King,WJ