Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers.
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers.
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DOI：
10.3390/ijms22126625
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发表时间：
2021-06-21
影响因子：
5.6
通讯作者：
Rolfo A
中科院分区：
文献类型：
--
作者：
Ermini L;Nuzzo AM;Ietta F;Romagnoli R;Moretti L;Masturzo B;Paulesu L;Rolfo A
双酚A（BPA）是一种合成苯酚，广泛用于聚碳酸酯塑料和环氧树脂的制造，也是液体和食品储存的一种成分。在可能归因于BPA的健康障碍中，特别研究了对新陈代谢的影响。BPA在产前生活中是一种危险，因为它存在于怀孕期间的组织和液体中。我们最近在喂食BPA的大鼠中进行的研究表明，胎盘葡萄糖1型转运蛋白（GLUT-1）增加，表明葡萄糖摄取量增加。然而，BPA对代谢功能障碍孕妇GLUT转运蛋白的作用尚未研究。在这项研究中，胎盘组织从26超重（OW）的妇女和32年龄匹配的正常体重（NW）的孕妇进行了检查GLUT 1和GLUT 4的表达。将来自OW和NW母体的胎盘外植体暴露于BPA 1 nM和1 μM，并检测GLUT表达。数据显示，不同的反应，胎盘外植体BPA的GLUT 1的表达与增加NW母亲和减少OW的。GLUT 4的表达是较低的外植体从OW比NW的母亲，而没有任何差异，OW和NW之间的胎盘活检的任何转运。
Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in prenatal life because of its presence in tissues and fluids during pregnancy. Our recent study in rats fed with BPA showed a placental increase in glucose type 1 transporter (GLUT-1), suggesting a higher uptake of glucose. However, the role of BPA on GLUT transporters in pregnant women with metabolic dysfunction has not yet been investigated. In this study, placental tissue from 26 overweight (OW) women and 32 age-matched normal weight (NW) pregnant women were examined for expression of GLUT1 and GLUT4. Placental explants from OW and NW mothers were exposed to BPA 1 nM and 1 μM and tested for GLUTs expression. The data showed a different response of placental explants to BPA in GLUT1 expression with an increase in NW mothers and a decrease in OW ones. GLUT4 expression was lower in the explants from OW than NW mothers, while no difference was showed between OW and NW in placental biopsies for any of the transporters.
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DOI：
10.1177/1559325815599173
发表时间：
2015-07
期刊：
Dose-response : a publication of International Hormesis Society
影响因子：
--
作者：
Bertoli S;Leone A;Battezzati A
通讯作者：
Battezzati A
影响因子：
9.8
作者：
Acosta, Ometeotl;Ramirez, Vanessa I.;Jansson, Thomas
通讯作者：
Jansson, Thomas
影响因子：
16.2
作者：
Black MH;Sacks DA;Xiang AH;Lawrence JM
通讯作者：
Lawrence JM
影响因子：
4.8
作者：
Garcia-Arevalo, Marta;Alonso-Magdalena, Paloma;Nadal, Angel
通讯作者：
Nadal, Angel
DOI：
10.1016/s0020-7292(15)30033-3
发表时间：
2015-10-01
影响因子：
3.8
作者：
Hod, Moshe;Kapur, Anil;Divakar, Hema
通讯作者：
Divakar, Hema