Wnt and the Wnt signaling pathway in bone development and disease.
Wnt and the Wnt signaling pathway in bone development and disease.
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DOI：
10.2741/4214
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Wang Y;Li YP;Paulson C;Shao JZ;Zhang X;Wu M;Chen W
Wnt信号既影响发育过程中发生的骨建模，也影响骨重建，骨重建是一个涉及组织更新的终身过程。尤其已知Wnt信号影响成骨细胞的分化。本文将Wnt信号通路分为经典通路和非经典通路两大分支，对Wnt信号通路的研究进展进行综述。经典途径也称为Wnt/β-连环蛋白途径。有两个主要的非经典途径：Wnt-平面细胞极性途径（Wnt-PCP途径）和Wnt-钙离子途径（Wnt-Ca 2+途径）。本文还讨论了Wnt配体、受体、细胞内效应物、转录因子和拮抗剂如何影响骨建模和骨重建过程。我们还回顾了Wnt配体，受体，细胞内效应，转录因子和拮抗剂在骨中的作用，如在小鼠模型中所示。Wnt信号传导中断与几种骨疾病有关，包括骨质疏松症、货车-布赫姆病和硬化性骨质疏松症。研究Wnt信号通路的作用机制及其与骨组织中其他信号通路的相互作用，将为治疗这些骨疾病提供潜在的治疗靶点。
Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two major branches: the canonical pathway and the noncanonical pathway. The canonical pathway is also called the Wnt/β-catenin pathway. There are two major noncanonical pathways: the Wnt-planar cell polarity pathway (Wnt-PCP pathway) and the Wnt-calcium pathway (Wnt-Ca2+ pathway). This review also discusses how Wnt ligands, receptors, intracellular effectors, transcription factors, and antagonists affect both the bone modeling and bone remodeling processes. We also review the role of Wnt ligands, receptors, intracellular effectors, transcription factors, and antagonists in bone as demonstrated in mouse models. Disrupted Wnt signaling is linked to several bone diseases, including osteoporosis, van Buchem disease, and sclerosteosis. Studying the mechanism of Wnt signaling and its interactions with other signaling pathways in bone will provide potential therapeutic targets to treat these bone diseases.
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DOI：
10.1083/jcb.201207142
发表时间：
2013-02-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Albers J;Keller J;Baranowsky A;Beil FT;Catala-Lehnen P;Schulze J;Amling M;Schinke T
通讯作者：
Schinke T
DOI：
10.1083/jcb.201008012
发表时间：
2011-03-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Albers J;Schulze J;Beil FT;Gebauer M;Baranowsky A;Keller J;Marshall RP;Wintges K;Friedrich FW;Priemel M;Schilling AF;Rueger JM;Cornils K;Fehse B;Streichert T;Sauter G;Jakob F;Insogna KL;Pober B;Knobeloch KP;Francke U;Amling M;Schinke T
通讯作者：
Schinke T
影响因子：
9.8
作者：
Ai, MR;Heeger, S;Schelling, DK
通讯作者：
Schelling, DK
影响因子：
64.8
作者：
Bhanot, P;Brink, M;Nusse, R
通讯作者：
Nusse, R
影响因子：
9.8
作者：
Bohring, Axel;Stamm, Thomas;Roepke, Albrecht
通讯作者：
Roepke, Albrecht