The Dementias Platform UK (DPUK) Data Portal

The Dementias Platform UK (DPUK) Data Portal
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英国痴呆症平台 (DPUK) 数据门户

DOI:
10.1101/582155
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发表时间:
2019
期刊:
--
影响因子:
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通讯作者:
Bauermeister S
Bauermeister S
中科院分区:
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文献类型:
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作者:
Bauermeister S

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英国痴呆症平台数据门户是一个数据存储库,便于访问42个队列中的337929个人的数据。Data Portal是一个端到端数据管理解决方案,为队列数据分析提供了一个安全的、完全可审计的远程访问环境。所有使用数据的项目都默认与生成数据的队列研究团队合作。数据门户使用UK Secure erresearch Platform基础设施提供三个核心实用程序:数据发现、访问和分析。这些服务使用7层架构交付,包括:数据摄取、数据管理、平台互操作性、数据发现、访问代理、数据分析和知识保存。自动化、简化和标准化的程序减少了所有利益相关者的管理负担,特别是涉及多个独立数据集的请求,其中单个请求可能被转发给多个数据控制器。研究人员使用VMware拥有自己的安全“实验室”,使用双因素身份验证访问。在过去两年,本署共收到160份项目建议,涉及579项个别群组资料查阅要求。这些申请来自16个国家72所机构(56所学术机构、13所商业机构、3所政府机构)的268名申请者,其中84份申请涉及多个群体。项目多种多样,包括多模态、机器学习和孟德尔随机分析。数据访问通常在使用点是免费的,尽管少数队列需要数据访问费。
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure ‘lab’ using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.
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