GPR87 promotes tumor cell invasion and mediates the immunogenomic landscape of lung adenocarcinoma.
GPR87 promotes tumor cell invasion and mediates the immunogenomic landscape of lung adenocarcinoma.
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GPR87促进肿瘤细胞侵袭并介导肺腺癌的免疫基因组景观。
DOI：
10.1038/s42003-022-03506-6
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发表时间：
2022-07-05
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
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作者：
The purpose of this study is to examine the association between G protein-coupled receptor 87 (GPR87) and lung adenocarcinoma (LUAD) metastasis and immune infiltration. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets extract clinical data. According to the TCGA database, increased GPR87 expression predicts poor overall survival, progression-free interval, and disease-specific survival in LUAD patients. The meta-analysis also reveals a significant association between high GPR87 expression and poor overall survival. Moreover, functional experiments demonstrate that GPR87 silencing reduces LUAD cell invasion and migration. Immunoblotting shows that GPR87 knockdown decreased Vimentin and N-cadherin expression and increased E-cadherin expression in LUAD cells. GPR87 expression in LUAD is positively correlated with immune infiltration. In addition, GPR87 expression is associated with immune and chemotherapy resistance in LUAD patients. Our findings indicate that GPR87 promotes tumor progression and is correlated with immune infiltration, suggesting GPR87 as a possible biomarker for prognosis prediction in LUAD. GPR87 is reported as a central player in lung adenocarcinoma and in resistance to immunotherapy, by promoting tumor cell invasion and mediating the immunogenomic landscape.
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影响因子：
--
作者：
Gugger M;White R;Song S;Waser B;Cescato R;Rivière P;Reubi JC
通讯作者：
Reubi JC
影响因子：
2
作者：
Giatromanolaki, Alexandra;Anestopoulos, Ioannis;Koukourakis, Michael I.
通讯作者：
Koukourakis, Michael I.
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS
影响因子：
5.2
作者：
Balduzzi, Sara;Ruecker, Gerta;Schwarzer, Guido
通讯作者：
Schwarzer, Guido
影响因子：
3.3
作者：
Cheng, Zhengwu;Shao, Xinyu;Wang, Junfeng
通讯作者：
Wang, Junfeng