Signals regulating myelination in peripheral nerves and the Schwann cell response to injury.
Signals regulating myelination in peripheral nerves and the Schwann cell response to injury.
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DOI：
10.1016/j.conb.2013.06.010
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发表时间：
2013-12
影响因子：
5.7
通讯作者：
Talbot WS
中科院分区：
文献类型：
--
作者：
Glenn TD;Talbot WS
在周围神经中，雪旺细胞形成髓磷脂，髓磷脂促进动作电位沿轴突的快速传导。髓鞘化雪旺细胞是由神经嵴祖细胞逐步分化而来的，受细胞外信号和转录因子的调控。除了形成髓鞘外，雪旺细胞还协调周围神经损伤后发生的大部分再生反应。在损伤反应中，髓鞘雪旺细胞脱分化为修复细胞，修复细胞是轴突再生所必需的，然后再分化为髓鞘雪旺细胞以恢复神经功能。尽管这种显著的可塑性早已被认识到，但许多关于调节髓鞘形成和雪旺细胞对损伤反应的信号通路的问题仍未得到解答。
In peripheral nerves, Schwann cells form myelin, which facilitates the rapid conduction of action potentials along axons in the vertebrate nervous system. Myelinating Schwann cells are derived from neural crest progenitors in a step-wise process that is regulated by extracellular signals and transcription factors. In addition to forming the myelin sheath, Schwann cells orchestrate much of the regenerative response that occurs after injury to peripheral nerves. In response to injury, myelinating Schwann cells dedifferentiate into repair cells that are essential for axonal regeneration, and then redifferentiate into myelinating Schwann cells to restore nerve function. Although this remarkable plasticity has long been recognized, many questions remain unanswered regarding the signaling pathways regulating both myelination and the Schwann cell response to injury.
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DOI：
10.1083/jcb.200912142
发表时间：
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期刊：
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影响因子：
--
作者：
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