Antibodies in Anti‐HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance

Antibodies in Anti‐HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance
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抗 HBe 阳性患者血清中的抗体与人肝癌细胞表面表达的 HBe 蛋白结合:对病毒清除的影响

DOI:
10.1002/hep.1840130109
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发表时间:
1991
期刊:
影响因子:
13.5
通讯作者:
L. Theilmann
L. Theilmann
中科院分区:
医学1区
文献类型:
--
作者:
H. Schlicht;A. von Brunn;L. Theilmann

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研究人员检查了最近描述的膜结合形式的 HBe 蛋白与抗病毒免疫反应的相关性。数据显示,抗 HBe 中的抗体(而非抗 HBc 阳性人血清中的抗体)能够有效地与膜表达的 HBe 结合。没有证据表明 HBc 能够以可以用人类抗体检测到的形式到达细胞表面。研究结果表明,从 HBe 血清转化为抗 HBe 后通常观察到的病毒滴度下降可能是抗体介导的感染细胞消除的结果。 (肝病学 1991;13:57-61)。
The relevance of the recently described membrane‐bound form of the HBe protein for the antiviral immune response was examined. The data show that antibodies in anti‐HBe, but not in anti‐HBc—positive human sera efficiently bind to the membrane expressed HBe. No evidence was obtained that the HBc can reach the cell surface in a form that can be detected with human antibodies. The findings suggest that the decline of virus titer that is usually observed after seroconversion from HBe to anti‐HBe might be the result of an antibody‐mediated elimination of infected cells. (HEPATOLOGY 1991;13:57–61).
DOI: 10.1073/pnas.83.6.1578
发表时间: 1986-03-01
影响因子: 11.1
作者:
OU, JH;LAUB, O;RUTTER, WJ
通讯作者: RUTTER, WJ
DOI: 10.1073/pnas.85.22.8405
发表时间: 1988-11-01
影响因子: 11.1
作者:
STANDRING, DN;OU, JH;RUTTER, WJ
通讯作者: RUTTER, WJ
DOI: 10.1126/science.1691527
发表时间: 1990-04-20
期刊: SCIENCE
影响因子: 56.9
作者:
MORIYAMA, T;GUILHOT, S;CHISARI, FV
通讯作者: CHISARI, FV