Antibodies in Anti‐HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance
Antibodies in Anti‐HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance
复制标题
抗 HBe 阳性患者血清中的抗体与人肝癌细胞表面表达的 HBe 蛋白结合:对病毒清除的影响
DOI:
10.1002/hep.1840130109
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发表时间:
1991
期刊:
影响因子:
13.5
通讯作者:
L. Theilmann
中科院分区:
文献类型:
--
作者:
H. Schlicht;A. von Brunn;L. Theilmann
The relevance of the recently described membrane‐bound form of the HBe protein for the antiviral immune response was examined. The data show that antibodies in anti‐HBe, but not in anti‐HBc—positive human sera efficiently bind to the membrane expressed HBe. No evidence was obtained that the HBc can reach the cell surface in a form that can be detected with human antibodies. The findings suggest that the decline of virus titer that is usually observed after seroconversion from HBe to anti‐HBe might be the result of an antibody‐mediated elimination of infected cells. (HEPATOLOGY 1991;13:57–61).
DOI:
10.1073/pnas.83.6.1578
发表时间:
1986-03-01
影响因子:
11.1
作者:
OU, JH;LAUB, O;RUTTER, WJ
通讯作者:
RUTTER, WJ
DOI:
10.1073/pnas.85.22.8405
发表时间:
1988-11-01
影响因子:
11.1
作者:
STANDRING, DN;OU, JH;RUTTER, WJ
通讯作者:
RUTTER, WJ
影响因子:
56.9
作者:
MORIYAMA, T;GUILHOT, S;CHISARI, FV
通讯作者:
CHISARI, FV