Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research.
Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research.
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DOI：
10.1016/j.nicl.2023.103507
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jack CR Jr
中科院分区：
文献类型：
--
作者：
Schwarz CG;Kremers WK;Weigand SD;Prakaashana CM;Senjem ML;Przybelski SA;Lowe VJ;Gunter JL;Kantarci K;Vemuri P;Graff-Radford J;Petersen RC;Knopman DS;Jack CR Jr
“去脸”软件是用来保护研究成像参与者的隐私的。我们测量了MRI_REFACE对AD研究生物标志物分析的影响。MRI_REFACE没有显著改变任何成像-生物标记物的相关性。脑成像研究越来越多地使用“去脸”软件在公共数据共享之前删除或替换面部图像。一些研究工作通过直接比较未修改和去脸图像的自动测量来研究去脸软件对脑成像生物标志物的影响，但大多数研究脑图像被用于分析与认知测量或临床状态的相关性，并且去脸软件对这些类型的成像-认知相关性的影响尚未被测量。在这项工作中，我们集中在阿尔茨海默病(AD)研究中使用的淀粉样蛋白(A)、tau(T)、神经变性(N)和血管(V)指标的脑成像测量。我们从三个年龄和性别匹配的临床组(认知正常组、轻度认知障碍组和AD痴呆组)创建了一个回顾性样本，并进行了区域和体素分析：海马体积(N)、白质高强度体积(V)、淀粉样蛋白PET(A)和tau PET(T)测量，每个测量来自多个软件管道，以了解他们区分认知定义的组的能力及其与年龄和临床痴呆症评分(CDR-SB)的相关程度。我们执行了两次这些分析：一次是使用未经修改的图像，另一次是使用领先的去脸软件MRI_REFace去表面的图像，我们直接比较了原始图像和去脸图像之间的发现及其统计强度。对原始图像和去脸图像的分析具有很高的一致性。在任何体素比较之间没有显著差异。在按区域进行的比较中，55个相关性中只有3个在原始图像和去面部图像之间有显著差异，经多次比较校正后这些相关性并不显著。总体而言，AD生物标志物的成像数据在未经修改的图像和去表面图像之间的统计能力几乎相同，它们的分析结果非常一致。
“de-facing” software is used to protect privacy of research imaging participants. We measured effects of mri_reface on analyses of AD research biomarkers. mri_reface did not significantly alter any imaging-biomarker correlations. Brain imaging research studies increasingly use “de-facing” software to remove or replace facial imagery before public data sharing. Several works have studied the effects of de-facing software on brain imaging biomarkers by directly comparing automated measurements from unmodified vs de-faced images, but most research brain images are used in analyses of correlations with cognitive measurements or clinical statuses, and the effects of de-facing on these types of imaging-to-cognition correlations has not been measured. In this work, we focused on brain imaging measures of amyloid (A), tau (T), neurodegeneration (N), and vascular (V) measures used in Alzheimer’s Disease (AD) research. We created a retrospective sample of participants from three age- and sex-matched clinical groups (cognitively unimpaired, mild cognitive impairment, and AD dementia, and we performed region- and voxel-wise analyses of: hippocampal volume (N), white matter hyperintensity volume (V), amyloid PET (A), and tau PET (T) measures, each from multiple software pipelines, on their ability to separate cognitively defined groups and their degrees of correlation with age and Clinical Dementia Rating (CDR)–Sum of Boxes (CDR-SB). We performed each of these analyses twice: once with unmodified images and once with images de-faced with leading de-facing software mri_reface, and we directly compared the findings and their statistical strengths between the original vs. the de-faced images. Analyses with original and with de-faced images had very high agreement. There were no significant differences between any voxel-wise comparisons. Among region-wise comparisons, only three out of 55 correlations were significantly different between original and de-faced images, and these were not significant after correction for multiple comparisons. Overall, the statistical power of the imaging data for AD biomarkers was almost identical between unmodified and de-faced images, and their analyses results were extremely consistent.
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影响因子：
4.8
作者：
Buimer EEL;Schnack HG;Caspi Y;van Haren NEM;Milchenko M;Pas P;Alzheimer's Disease Neuroimaging Initiative;Hulshoff Pol HE;Brouwer RM
通讯作者：
Brouwer RM
影响因子：
4.7
作者：
Rubbert C;Wolf L;Turowski B;Hedderich DM;Gaser C;Dahnke R;Caspers J;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
5.7
作者：
Schwarz, Christopher G.;Kremers, Walter K.;Lowe, Val J.;Savvides, Marios;Gunter, Jeffrey L.;Senjem, Matthew L.;Vemuri, Prashanthi;Kantarci, Kejal;Knopman, David S.;Petersen, Ronald C.;Jack Jr, Clifford R.
通讯作者：
Jack Jr, Clifford R.
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC