Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.
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伪装的饮食周期减少了神经炎症，从而减轻了阿尔茨海默氏症模型的认知能力下降。
DOI：
10.1016/j.celrep.2022.111417
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发表时间：
2022-09-27
期刊：
影响因子：
8.8
通讯作者：
Longo, Valter D.
中科院分区：
文献类型：
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作者：
Rangan, Priya;Lobo, Fleur;Parrella, Edoardo;Rochette, Nicolas;Morselli, Marco;Stephen, Terri-Leigh;Cremonini, Anna Laura;Tagliafico, Luca;Persia, Angelica;Caffa, Irene;Monacelli, Fiammetta;Odetti, Patrizio;Bonfiglio, Tommaso;Nencioni, Alessio;Pigliautile, Martina;Boccardi, Virginia;Mecocci, Patrizia;Pike, Christian J.;Cohen, Pinchas;LaDu, Mary Jo;Pellegrini, Matteo;Xia, Kyle;Tran, Katelynn;Ann, Brandon;Chowdhury, Dolly;Longo, Valter D.
模拟禁食饮食（FMD）周期在减少许多衰老和疾病危险因素方面的作用表明它可能影响阿尔茨海默病（AD）。在E4FAD和3xTg AD小鼠模型中，FMD周期减少认知能力下降和AD病理，其效果优于蛋白质限制周期。在3xTg小鼠中，长期FMD循环减少海马Aβ负荷和过度磷酸化的tau，增强神经干细胞的发生，减少小胶质细胞数量，降低神经炎症基因的表达，包括产生超氧化物的NADPH氧化酶（Nox2）。与对照组相比，缺乏Nox2的3xTg小鼠或NADPH氧化酶抑制剂罗布麻碱处理的小鼠也表现出认知能力的改善和小胶质细胞激活的降低。临床数据表明，口蹄疫周期在一小部分AD患者中是可行的，并且通常是安全的。这些结果表明，口蹄疫周期部分通过减少神经炎症和/或大脑中超氧化物的产生来延缓AD模型的认知能力下降。Rangan等人的研究表明，在AD小鼠模型中，模拟禁食饮食（FMD）周期可以减轻认知能力下降，减少阿尔茨海默病病理，减少神经炎症，并增强神经发生。他们还表明，在一小部分阿尔茨海默病患者中，类似的FMD是安全可行的。
The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk factors indicate it could affect Alzheimer’s disease (AD). Here, we show that FMD cycles reduce cognitive decline and AD pathology in E4FAD and 3xTg AD mouse models, with effects superior to those caused by protein restriction cycles. In 3xTg mice, long-term FMD cycles reduce hippocampal Aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating NADPH oxidase (Nox2). 3xTg mice lacking Nox2 or mice treated with the NADPH oxidase inhibitor apocynin also display improved cognition and reduced microglia activation compared with controls. Clinical data indicate that FMD cycles are feasible and generally safe in a small group of AD patients. These results indicate that FMD cycles delay cognitive decline in AD models in part by reducing neuroinflammation and/or superoxide production in the brain. Rangan et al. show that cycles of a fasting-mimicking diet (FMD) attenuate cognitive decline and reduce Alzheimer’s disease pathology, reduce neuroinflammation, and enhance neurogenesis in AD mouse models. They also show that a similar FMD is safe and feasible in a small group of AD patients.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
2.4
作者：
Block, Michelle L.
通讯作者：
Block, Michelle L.
影响因子：
4.5
作者：
Baillie JK;Arner E;Daub C;De Hoon M;Itoh M;Kawaji H;Lassmann T;Carninci P;Forrest AR;Hayashizaki Y;FANTOM Consortium;Faulkner GJ;Wells CA;Rehli M;Pavli P;Summers KM;Hume DA
通讯作者：
Hume DA
影响因子：
7.8
作者：
Caccamo A;Magrì A;Medina DX;Wisely EV;López-Aranda MF;Silva AJ;Oddo S
通讯作者：
Oddo S
影响因子：
9.3
作者：
Biechele G;Franzmeier N;Blume T;Ewers M;Luque JM;Eckenweber F;Sacher C;Beyer L;Ruch-Rubinstein F;Lindner S;Gildehaus FJ;von Ungern-Sternberg B;Cumming P;Bartenstein P;Rominger A;Höglinger GU;Herms J;Brendel M
通讯作者：
Brendel M