Dipivefrin reduces blood flow in the ciliary body in humans.
Dipivefrin reduces blood flow in the ciliary body in humans.
复制标题
地匹福林可减少人体睫状体的血流量。
DOI：
10.1016/s0161-6420(94)31281-4
复制
发表时间：
1994
期刊：
影响因子：
13.7
通讯作者：
M. Groh
中科院分区：
文献类型：
--
作者：
G. Michelson;M. Groh
目的：肾上腺素能物质广泛应用于青光眼的降眼压治疗。肾上腺素能药物降低眼压的假说机制是睫状体血流量减少和直接受体相关的房水产生减少。本研究的目的是无创性地测量人局部应用地吡夫林后葡萄膜前区的血流量。方法：用激光多普勒血流仪测量虹膜和睫状体的血流量。激光多普勒血流仪、血流量和心电图结果同时测量并保存3分钟。在作者的装置中，激光通过光纤经角膜投射到虹膜上，或从角膜缘向睫状体投射2 mm。为了提高信噪比，对R波触发的数字化激光多普勒血流计信号(平均激光多谱勒血流计)进行了平均100次扫描，每次扫描2秒，以改善信噪比。利用该方法建立了虹膜和睫状体血流的收缩极大值和舒张期极小值的重复性脉搏曲线。采用双盲研究设计，对33名健康青年(平均年龄25±7岁)，外用0.9%滴眼液，观察其对虹膜和睫状体血流的影响。结果：滴眼液显著降低睫状体平均血流量(平均49%)。萘甲唑啉和氯化钠溶液不改变睫状体的血流量。联苯呋喃、萘甲唑啉和0.9%氯化钠对虹膜血流量无明显影响。结论：观察数据提示，联苯呋喃降低了睫状体血流量。
Purpose:Adrenergic substances are used widely for lowering intraocular pressure in the treatment of glaucoma. The hypothetic mechanisms for lowering the intraocular pressure by adrenergic drugs are decreased blood flow in the ciliary body and direct receptor-related reduction of aqueous humor production. The aim of this study is to measure noninvasively the blood flow in the anterior uvea in humans after topically administered dipivefrin.Method:The blood flow of iris and ciliary body was measured by laser Doppler flowmetry. Laser Doppler flowmetry blood flow and results of the electrocardiogram were simultaneously measured and stored over a period of 3 minutes. In the authors' setup, laser light was projected by a fiber optic transcorneally onto the iris or 2 mm transscerally from the limbus into the ciliary body. For improvement of the signal-tonoise ratio, a statistical averaging procedure was performed by averaging 100 sweeps of 2 seconds of the digitalized laser Doppler flowmetry signals triggered by the R-onset of the electrocardiogram (averaging laser Doppler flowmetry). Using this method, reproducible pulse curves of blood flow of iris and ciliary body were established with systolic maxima and diastolic minima. In a double-blind study design involving 33 young, healthy persons (mean age, 25 ± 7 years), the effect of topically administered dipivefrin, naphazoline, and NaCl solution (0.9%) on the blood flow of iris and ciliary body was examined.Results:Dipivefrin reduces significantly (average, 49%) the mean blood flow in the ciliary body. Naphazoline and NaCl solution do not change the blood flow in the ciliary body. Dipivefrin, naphazoline, and 0.9% NaCl show no significant effect on the iridal blood flow.Conclusion:The observed data suggest that dipivefrin decreases ciliary body blood flow.
人虹膜睫状体中β-肾上腺素能受体的分布和特性。
影响因子：
4.4
作者：
Wax,MB;Molinoff,PB
通讯作者：
Molinoff,PB
脉络膜血管系统的β-肾上腺素能反应性。
影响因子：
13.7
作者：
Grajewski,AL;Ferrari-Dileo,G;Feuer,WJ;Anderson,DR
通讯作者：
Anderson,DR