In vivo antifungal efficacy of salivary histidine-rich polypeptides: preliminary findings in a denture stomatitis model system.
In vivo antifungal efficacy of salivary histidine-rich polypeptides: preliminary findings in a denture stomatitis model system.
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唾液富含组氨酸的多肽的体内抗真菌功效：义齿口腔炎模型系统的初步发现。
DOI：
10.1016/0022-3913(91)90455-6
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Gwinnett,AJ
中科院分区：
文献类型：
--
作者：
Santarpia3rd,RP;Pollock,JJ;Renner,RP;Gwinnett,AJ
在这项初步研究中，6名义齿口炎患者的上颌义齿和腭部组织表面均发现有白色念珠菌，他们自愿参加了这项初步研究，以测试人唾液抗真菌富含组氨酸多肽(HRPs)对他们口腔疾病的体内疗效。患者被平均分为牛顿型患者，正如预期的那样，牛顿III型患者的炎症严重程度最大，而牛顿I型患者的炎症严重程度最小。患者接受HRP-3或HRP-4的无菌溶液，他们同时使用这两种溶液作为口腔喷雾剂和假牙浸泡，为期1周。上颌义齿的组织贴合面的琼脂复制品显示HRP减少和/或消除了FC。在一名牛顿II型患者中，这一发现与特定部位的腭部炎症减少直接相关。在牛顿II型和III型患者中，炎症有显著的普遍减少，这表明高密度脂蛋白的治疗效果。如扫描电子显微镜(SEM)所确定的，HRP对这种酵母菌的杀灭可能是本研究中观察到的临床益处的原因。在扫描电子显微镜下，经HRP处理的囊孢子看起来严重泄气，就像它们被排空了大量的细胞内物质一样。
Six denture stomatitis patients, all found to haveCandida albicanson their maxillary denture and palatal tissue surfaces, volunteered in this preliminary study to test the in vivo efficacy of human salivary antifungal histidine-rich polypeptides (HRPs) in treating their oral disease. The patients were equally divided among the Newton types classification and, as expected, the severity of the inflammation was greatest in the Newton type III patients and least in the Newton type I patients. Patients received sterile solutions of either HRP-3 or HRP-4, which they used both as a mouthrinse and as a denture soak for a period of 1 week. Agar replicas of the tissue-fitting surface of the maxillary dentures revealed HRP reduction and/or elimination ofC. albicansfrom the denture; in one Newton type II individual, this finding directly correlated with a site-specific reduction in palatal inflammation. In the Newton type II and type III individuals alike, there was a significant generalized decrease in inflammation suggesting the therapeutic efficacy of the HRPs. Killing of this yeast species by the HRPs, as determined by scanning electron microscopy (SEM), was probably responsible for the observed clinical benefits noted in this investigation. In the SEM, HRP-treated blastospores appeared severely deflated, as if they had been emptied of significant quantities of intracellular material.
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组氨酸肽和酮康唑对白色念珠菌芽生孢子活力和芽管发育的抑制作用的比较。
影响因子：
3
作者：
Santarpia3rd,RP;Brant,EC;Lal,K;Brasseur,MM;Hong,AL;Pollock,JJ
通讯作者：
Pollock,JJ
营养因素和口腔念珠菌病。
DOI：
--
发表时间：
1986
期刊：
Journal of oral pathology
影响因子：
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作者：
L. Samaranayake
通讯作者：
L. Samaranayake
装假牙嘴疼。
DOI：
--
发表时间：
1987
期刊：
Dermatologia clinica
影响因子：
--
作者：
C. M. Reeve;N. V. van Roekel
通讯作者：
N. V. van Roekel
影响因子：
6.4
作者：
KIRKPATRICK, CH;GREEN, I;SCHADE, AL
通讯作者：
SCHADE, AL
念珠菌属对溶菌酶的体外敏感性。
影响因子：
--
作者：
Rs Tobgi;L. Samaranayake;T. MacFarlane
通讯作者：
T. MacFarlane