Beyond cervical length: emerging technologies for assessing the pregnant cervix.
Beyond cervical length: emerging technologies for assessing the pregnant cervix.
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DOI：
10.1016/j.ajog.2012.05.015
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发表时间：
2012-11
影响因子：
9.8
通讯作者：
Berghella, Vincenzo
中科院分区：
文献类型：
--
作者：
Feltovich, Helen;Hall, Timothy J.;Berghella, Vincenzo
自发性早产是一种异质表型。多种病理生理途径最终导致宫颈软化、缩短和扩张，从而导致早产。如果我们要确定与每个独特途径相关的致病上游分子过程和由此产生的生物力学事件，则必须精确描述宫颈的特定显微结构变化。然而，目前我们还没有可靠的临床工具进行定量和客观的评估，这可能是单胎自发性早产率在100多年来没有明显变化的原因。幸运的是，有前途的技术，以评估组织水化，胶原蛋白结构和/或组织弹性正在出现。这些将增加有关宫颈的知识，促进分子研究的协调，最终导致早产预测和预防的新方法。
Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular processes and resultant biomechanical events associated with each unique pathway. Currently, however, we have no reliable clinical tools for quantitative and objective evaluation, which likely contributes to the reason the singleton spontaneous preterm birth rate has not appreciably changed in more than 100 years. Fortunately, promising techniques to evaluate tissue hydration, collagen structure and/or tissue elasticity are emerging. These will add to the body of knowledge about the cervix and facilitate coordination of molecular studies, ultimately leading to novel approaches to preterm birth prediction and, finally, prevention.
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影响因子：
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作者：
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通讯作者：
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发表时间：
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