Health-Related Quality of Life and Depression Symptoms in a Cross Section of Patients with Advanced Lung Cancer before and during the COVID-19 Pandemic.
Health-Related Quality of Life and Depression Symptoms in a Cross Section of Patients with Advanced Lung Cancer before and during the COVID-19 Pandemic.
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COVID-19 大流行之前和期间晚期肺癌患者的健康相关生活质量和抑郁症状。
DOI：
10.1089/jpm.2022.0049
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发表时间：
2022
影响因子：
2.8
通讯作者：
Greer,JosephA
中科院分区：
文献类型：
--
作者：
Petrillo,LauraA;El-Jawahri,Areej;Heuer,LaurenB;Post,Kathryn;Gallagher,EmilyR;Trotter,Chardria;Elyze,Madeleine;Vyas,Charu;Plotke,Rachel;Turk,YaelR;Han,Jacqueline;Temel,JenniferS;Greer,JosephA
背景：患有晚期肺癌的成年人在诊断时降低了健康相关的生活质量（HRQOL）和心理症状。目的：本研究旨在评估COVID-19大流行是否使最近诊断为癌症的患者的HRQOL恶化。设计：我们分析了两项早期姑息治疗随机对照试验的基线数据，以比较大流行期间入组的患者的HRQOL和抑郁症状。（2020年1月至2021年1月）与大流行前相比（2018年3月至2019年1月）。设置/受试者：该队列包括两项多中心研究中最近诊断为晚期肺癌的患者。我们使用协方差分析来计算组间的校正平均差异，以时间范围作为自变量，（使用癌症治疗功能评估-一般）和抑郁症状（使用患者健康问卷-9）作为因变量，调整年龄、性别、关系状态、表现状态、症状和自诊断以来的时间。结果：在调整后的分析中，新冠肺炎前入组的患者（n= 665）与新冠肺炎期间入组的患者（n= 191）之间的HRQOL（调整后均值差-1.78;p = 0.137）和抑郁症状（0.06;p= 0.889）均无差异。关系状况缓和了COVID-19时间框架对HRQOL的影响;未婚患者在COVID-19期间的HRQOL更差（校正平均差异：−5.25;p= 0.011）。结论：COVID-19大流行并未进一步降低近期诊断为肺癌的患者的HRQOL或增加抑郁症状，但在适度分析中确实恶化了未婚患者的HRQOL。心理社会评估和支持性护理对所有患者都很重要，特别是那些社会支持有限的患者。临床试验注册号：NCT 03337399和NCT 03375489
Background:Adults with advanced lung cancer experience reduced health-related quality of life (HRQOL) and psychological symptoms at diagnosis.Objective:This study aimed to evaluate whether the COVID-19 pandemic worsened HRQOL among patients recently diagnosed with cancer.Design:We analyzed baseline data from two randomized controlled trials of early palliative care to compare HRQOL and depression symptoms among those enrolled during the pandemic (January 2020 to January 2021) versus prepandemic (March 2018 to January 2019).Setting/Subjects:This cohort included patients recently diagnosed with advanced lung cancer in two multisite studies.Measurements:We used analysis of covariance to calculate adjusted mean differences between groups with the timeframe as an independent variable and HRQOL (using the Functional Assessment of Cancer Therapy-General) and depression symptoms (using the Patient Health Questionnaire-9) as dependent variables, adjusting for age, gender, relationship status, performance status, symptoms, and time since diagnosis. We tested for an interaction between the COVID-19 timeframe and relationship status.Results:Neither HRQOL (adjusted mean difference −1.78;p= 0.137) nor depression symptoms (0.06;p= 0.889) differed between patients enrolled pre-COVID-19 (n= 665) relative to those enrolled during COVID-19 (n= 191) in adjusted analyses. Relationship status moderated the effect of the COVID-19 timeframe on HRQOL; unmarried patients experienced worse HRQOL during COVID-19 (adjusted mean difference: −5.25;p= 0.011).Conclusions:The COVID-19 pandemic did not further reduce HRQOL or increase depression symptoms among patients recently diagnosed with lung cancer, but did worsen HRQOL for unmarried patients in moderation analysis. Psychosocial evaluation and supportive care are important for all patients, particularly those with limited social support. Clinical trial registration numbers: NCT03337399 and NCT03375489
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