Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.
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DOI：
10.2174/138161211798999438
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发表时间：
2011-12
影响因子：
3.1
通讯作者：
Camarero JA
中科院分区：
文献类型：
--
作者：
Gould A;Ji Y;Aboye TL;Camarero JA
环肽是一个独特的和不断增长的家庭骨干环化肽，也含有一个胱氨酸结基序建立从六个保守的半胱氨酸残基。这种独特的环状骨架拓扑结构和三个二硫键的打结排列使它们与其他类似大小的肽相比对热、化学和酶降解特别稳定。除了形成胱氨酸结的保守残基之外，环肽已经显示在其序列中具有高变异性。由超过160个已知成员组成，环肽具有许多生物活性，包括抗HIV、抗微生物、溶血和子宫收缩能力;此外，一些环肽已被证明具有细胞穿透性质。最初从植物中发现和分离，环肽也可以合成和重组产生。环肽的高序列可变性、稳定性和细胞穿透性质使它们成为用于移植已知活性肽或工程肽基药物设计的潜在支架。本综述报告了天然和工程化环肽的生物多样性和治疗潜力的最新研究结果。
Cyclotides are a unique and growing family of backbone cyclized peptides that also contain a cystine knot motif built from six conserved cysteine residues. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to thermal, chemical, and enzymatic degradation compared to other peptides of similar size. Aside from the conserved residues forming the cystine knot, cyclotides have been shown to have high variability in their sequence. Consisting of over 160 known members, cyclotides have many biological activities, ranging from anti-HIV, antimicrobial, hemolytic, and uterotonic capabilities; additionally, some cyclotides have been shown to have cell penetrating properties. Originally discovered and isolated from plants, cyclotides can be also produced synthetically and recombinantly. The high sequence variability, stability, and cell penetrating properties of cyclotides make them potential scaffolds to be used to graft known active peptides or engineer peptide-based drug design. The present review reports recent findings in the biological diversity and therapeutic potential of natural and engineered cyclotides.
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影响因子：
4.9
作者：
Camarero, JA;Muir, TW
通讯作者：
Muir, TW
影响因子：
3.6
作者：
Camarero, JA;Hackel, BJ;Mitchell, AR
通讯作者：
Mitchell, AR
影响因子：
5.1
作者：
Chen, B;Colurave, ML;Craik, DJ
通讯作者：
Craik, DJ
影响因子：
4.8
作者：
Chen, B;Colgrave, ML;Craik, DJ
通讯作者：
Craik, DJ
影响因子：
3.5
作者：
Camarero, JA;Fushman, D;Muir, TW
通讯作者：
Muir, TW