Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons
Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons
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茶多酚通过调节海马神经元中的 BDNF-TrkB/Akt 和 Erk1/2 信号轴来减弱星孢菌素诱导的细胞毒性和细胞凋亡
DOI：
10.1016/j.ibror.2020.04.002
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发表时间：
2020-04
期刊：
影响因子：
2.6
通讯作者：
Xiao-Yan Qin
中科院分区：
文献类型：
--
作者：
Jian-Rong Yang;Teng-Teng Ren;Rongfeng Lan;Xiao-Yan Qin
Tea polyphenols (TP) are the major ingredients in tea beverages that display health-benefits including anti-oxidation, anti-inflammation, anti-aging, attenuating blood pressure and deflating. In this study, we investigated the neuroprotective effects of TP to attenuate staurosporine (STS)-induced cytotoxicity. Rat hippocampal neurons were isolated, cultured and incubated with STS to induce neurite collapse and apoptosis, however, the medication of TP eliminated these adverse effects and maintained the morphology of neurons. STS decreased the expression of pro-BDNF, downregulated the TrkB/Akt/Bcl-2 signaling axis and promoted the activation of Erk1/2 and caspase-3. In contrast, TP rescued the expression of pro-BDNF and antagonistically restored the biochemistry of aforementioned signaling effectors. Consistently, the activity of TP can be attenuated by the inhibition of TrkB or Akt by small chemicals K252a and LY294002. Therefore, BDNF-TrkB and Akt signaling axis is essential for TP-mediated neuroprotective effects. In summary, TP showed beneficial effects to protect neurons from exogenous insults such as STS-induced neural cytotoxicity and cell death.
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影响因子：
12.4
作者：
Deshmukh, M;Johnson, EM
通讯作者：
Johnson, EM
影响因子：
3.9
作者：
Lambert JD;Elias RJ
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Elias RJ
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5.6
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DOI：
10.2741/s286
发表时间：
2012
期刊：
Frontiers in bioscience
影响因子：
--
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通讯作者：
S. Mandel;O. Weinreb;T. Amit;M. Youdim