Translation Control by Adenovirus Virus-Associated RNA I
Translation Control by Adenovirus Virus-Associated RNA I
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腺病毒病毒相关 RNA I 的翻译控制
DOI：
10.1007/978-1-4615-2894-4_10
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发表时间：
1993
期刊：
影响因子：
1.7
通讯作者：
S. Swaminathan
中科院分区：
文献类型：
--
作者：
B. Thimmapaya;G. Ghadge;P. Rajan;S. Swaminathan
腺病毒首先由Rowe及其同事从人类腺样组织中分离出来，因此被称为腺病毒。它们是无包膜的DNA病毒，仅由DNA和蛋白质组成，并且在自然界中广泛存在。到目前为止，在93种病毒株中，有41种是人类来源的，其余的是从猴子、狗、牛、啮齿动物和鸟类中分离出来的。1 -3临床研究表明，这些病毒可引起人类多种疾病，其中大部分涉及呼吸道、眼睛和胃肠道。在大多数情况下，这些感染导致自限性疾病或潜伏的持续感染，通常随后完全康复。腺病毒可以在宿主动物体内维持隐性感染数月甚至数年。类淋巴细胞可作为这些持续性感染的储库。该组的几个成员也可以在新生啮齿动物中诱导恶性肿瘤，因此腺病毒被归类为DNA肿瘤病毒组的成员。到目前为止，这一组的所有成员都被证明可以在培养中转化啮齿动物细胞。4尽管这些病毒在实验模型中具有致瘤潜力，但这些病毒在人类中没有致瘤性。腺病毒可以在多种培养的哺乳动物细胞中生长至高滴度。上皮来源的人细胞最适合于生长人腺病毒。由于其基因组的小尺寸，它们可以在快速生长的培养细胞中生长的容易性，以及它们在体外转化啮齿动物细胞的能力，腺病毒已经作为研究真核基因表达调控和病毒-宿主-细胞相互作用的重要模型系统。
Adenoviruses were first isolated by Rowe and co-workers from human adenoid tissues—hence the name adenoviruses. These are nonenveloped DNA viruses, composed of only DNA and proteins, and are widespread in nature. Forty-one of the 93 strains identified so far are of human origin, while the rest have been isolated from monkeys, dogs, cattle, rodents, and birds.1–3 Clinical studies have shown that these viruses can cause a variety of diseases in humans, most of which involve the respiratory tract, the eye, and the gastrointestinal tract. For the most part, these infections lead to self-limited illnesses or latent persistent infections and are usually followed by complete recovery. Adenoviruses can maintain inapparent infections within host animals for months or even years. Lymphoid cells may serve as reservoirs for these persistent infections. Several members of this group can also induce malignant tumors in newborn rodents and therefore adenoviruses are classified as members of the DNA tumor virus group. All the members of this group tested so far have been shown to transform rodent cells in culture.4 Despite their tumorigenic potential in experimental models, these viruses have not been shown to be tumorigenic in humans. Adenoviruses can be grown to high titers in a variety of cultured mammalian cells. Human cells of epithelial origin are best suited for growing human adenoviruses. Because of the small size of their genome, the ease with which they can be grown in rapidly growing cultured cells, and their ability to transform rodent cells in vitro, adenoviruses have served as important model systems to study the regulation of eukaryotic gene expression and virus-host-cell interactions.
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痘苗病毒对干扰素的耐药性与病毒与干扰素系统之间的干扰现象有关。
影响因子：
3.7
作者：
Paez,E;Esteban,M
通讯作者：
Esteban,M
DOI：
10.1073/pnas.78.6.3378
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GUILFOYLE, R;WEINMANN, R
通讯作者：
WEINMANN, R
DOI：
10.1073/pnas.88.4.1546
发表时间：
1991-02
影响因子：
11.1
作者：
S. Swaminathan;B. Tomkinson;E. Kieff
通讯作者：
S. Swaminathan;B. Tomkinson;E. Kieff
腺病毒的翻译控制：腺病毒感染期间缺乏病毒相关的 RNAI 会导致起始因子 eIF-2 磷酸化并抑制蛋白质合成。
DOI：
10.1073/pnas.82.7.1959
发表时间：
1985
影响因子：
11.1
作者：
Siekierka,J;Mariano,TM;Reichel,PA;Mathews,MB
通讯作者：
Mathews,MB
影响因子：
3.7
作者：
P. Whitaker-Dowling;J. Youngner
通讯作者：
P. Whitaker-Dowling;J. Youngner