Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume.
Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume.
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DOI：
10.1186/ar2132
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发表时间：
2007
影响因子：
4.9
通讯作者：
Jones G
中科院分区：
文献类型：
--
作者：
Ding C;Martel-Pelletier J;Pelletier JP;Abram F;Raynauld JP;Cicuttini F;Jones G
我们进行了一项纵向研究（持续2年），包括294名个体（平均年龄45岁，58%为女性），以检查在大部分非骨关节炎队列中，股骨突出、膝关节结构、影像学变化和骨关节炎（OA）风险因素之间的相关性。半月板挤压，胫股软骨缺损评分和软骨体积，胫骨平台骨面积采用T1加权脂肪饱和磁共振成像。在基线时，内侧髁突出与体重指数显著相关（比值比[OR]/kg/m2 = 1.13，95%置信区间[CI] = 1.02-1.25），既往膝关节损伤（积极与消极的历史：OR = 3.73，95%CI = 1.16-11.97），胫骨内侧骨面积（OR/cm 2 = 1.37，95% CI = 1.02-1.85）和骨赘（OR/等级= 4.89，95% CI = 1.59-15.02）。2年纵向数据显示，基线时内侧胫骨突出与内侧胫股软骨体积丢失率较高相关（挤压与无挤压：-1.4%/年; P < 0.05）和增加内侧股骨软骨缺损的风险（OR = 2.59，95% CI = 1.14-5.86）和胫骨外侧软骨缺损（OR = 2.64，95% CI = 1.03-6.76）。然而，在调整胫骨面积和骨赘后，后两种相关性变得不显著。这项研究表明，增加体重指数和骨大小，过去的膝盖受伤，骨赘可能是因果关系与股骨挤出。最重要的是，基线时的骨外挤与2年内膝关节软骨的更大损失相关，这似乎主要由软骨下骨变化介导，表明骨外挤代表了骨扩张和软骨损失之间的一种途径。
We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone area were determined using T1-weighted fat-saturated magnetic resonance imaging. At baseline the presence of medial meniscal extrusion was significantly associated with body mass index (odds ratio [OR] per kg/m2 = 1.13, 95% confidence interval [CI] = 1.02–1.25), past knee injury (positive versus negative history: OR = 3.73, 95% CI = 1.16–11.97), medial tibial bone area (OR per cm2 = 1.37, 95% CI = 1.02–1.85), and osteophytes (OR per grade = 4.89, 95% CI = 1.59–15.02). Two-year longitudinal data revealed that medial meniscal extrusion at baseline was associated with a greater rate of loss of medial tibiofemoral cartilage volume (extrusion versus no extrusion: -1.4%/year; P < 0.05) and greater risk for increased medial femoral cartilage defects (OR = 2.59, 95% CI = 1.14–5.86) and lateral tibial cartilage defects (OR = 2.64, 95% CI = 1.03–6.76). However, the latter two associations became nonsignificant after adjustment for tibial bone area and osteophytes. This study suggests that increasing body mass index and bone size, past knee injury, and osteophytes may be causally related to meniscal extrusion. Most importantly, meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, and this seems to be mediated mostly by subchondral bone changes, suggesting extrusion represents one pathway between bone expansion and cartilage loss.
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影响因子：
7
作者：
Jones, G;Ding, CH;Cicuttini, FM
通讯作者：
Cicuttini, FM
影响因子：
--
作者：
Ding, CH;Cicuttini, FM;Jones, G
通讯作者：
Jones, G
影响因子：
--
作者：
Hunter, DJ;Zhang, YQ;Felson, DT
通讯作者：
Felson, DT
影响因子：
7
作者：
Ding, CH;Garnero, P;Jones, G
通讯作者：
Jones, G
影响因子：
--
作者：
Raynauld, JP;Martel-Pelletier, J;Pelletier, JP
通讯作者：
Pelletier, JP