Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability.
Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability.
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DOI：
10.1007/s10519-009-9269-9
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发表时间：
2009-05
影响因子：
2.6
通讯作者：
Clark, Duncan B.
中科院分区：
文献类型：
--
作者：
Vanyukov, Michael M.;Kirisci, Levent;Moss, Lisa;Tarter, Ralph E.;Reynolds, Maureen D.;Maher, Brion S.;Kirillova, Galina P.;Ridenour, Ty;Clark, Duncan B.
无法量化疾病的风险，如物质使用障碍（SUD），阻碍了病因学研究和有针对性的干预措施的发展。基于与非法药物有关的SUD的共同传染责任的概念，已经开发了一种能够量化这种潜在特征的方法，利用高风险设计和项目反应理论。本研究探讨了使用这种方法得出的SUD传染责任指数（TLI）的属性。从青春期前到青年期，对患有或不患有SUD的男性的儿子进行了纵向研究。TLI的属性，包括其心理测量学特征，纵向风险评估和种族差异，进行了检查。进行了一项试点双胞胎研究，以分析TLI的表型方差的组成。数据表明，TLI具有并发，增量，预测和判别效度，以及种族差异。这些数据表明，男性的指数具有较高的遗传力。结果表明，遗传和其他病因学相关的研究，并评估个人的风险的方法的适用性。
The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI’s phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.
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影响因子：
--
作者：
Merikangas, KR;Stolar, M;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
DOI：
10.1080/19485565.1980.9988401
发表时间：
1980-01-01
期刊：
SOCIAL BIOLOGY
影响因子：
--
作者：
RICE, J;CLONINGER, CR;REICH, T
通讯作者：
REICH, T
DOI：
10.1375/136905202320906363
发表时间：
2002-10-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Strassberg, M;Peters, K;Vanyukov, M
通讯作者：
Vanyukov, M
影响因子：
17.7
作者：
Tarter, Ralph E.;Vanyukov, Michael;Clark, Duncan B.
通讯作者：
Clark, Duncan B.
影响因子：
0.9
作者：
Jenkins, Elizabeth A.;Maher, Brion S.;Vanyukov, Michael M.
通讯作者：
Vanyukov, Michael M.