Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents

Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents
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鉴定一种能够增强河豚毒素敏感钠电流的新型 M 超家族芋螺毒素

DOI:
10.1007/s00204-009-0453-8
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发表时间:
2009-06
影响因子:
6.1
通讯作者:
Xu, Anlong
Xu, Anlong
中科院分区:
医学2区
文献类型:
--
作者:
Pi, Canhui;Wang, Lei;Ren, Zhenghua;Zeng, Xiayun;Chen, Shangwu;Jiang, Xiaoyu;Zhou, Maojun;Liu, Junliang;Xu, Anlong

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本研究从石纹芋螺(Conus litteratus)粗毒中分离纯化了一种新的M-超家族芋螺毒素,命名为lt 3a。结合肽段测序、MALDI-TOF质谱和cDNA克隆技术,推测lt 3a的氨基酸序列
In this work, a novel M-superfamily conotoxin, designated lt3a, was purified from the crude venom of Conus litteratus. Combined with peptide sequencing, MALDI-TOF mass spectrometry and cDNA cloning techniques, the amino acid sequence of lt3a was supposed
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