MicroRNA Regulation of RNA Virus Replication and Pathogenesis.
MicroRNA Regulation of RNA Virus Replication and Pathogenesis.
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DOI：
10.1016/j.molmed.2016.11.003
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发表时间：
2017-01
影响因子：
13.6
通讯作者：
Klimstra WB
中科院分区：
文献类型：
--
作者：
Trobaugh DW;Klimstra WB
microRNA（miRNAs）是非编码RNA，其通过与mRNA直接结合并影响翻译效率或mRNA丰度来操纵蛋白质水平，从而调节细胞内的许多过程。最近的证据表明，miRNA还可以通过直接结合RNA病毒基因组或通过病毒介导的宿主转录组的变化来影响RNA病毒的复制和发病机制。本文综述了RNA病毒与细胞miRNA相互作用的研究进展。我们还讨论了细胞和组织特异性表达的miRNA如何直接影响病毒的发病机制。了解细胞miRNA在病毒感染过程中的作用可能会导致识别阻断RNA病毒复制或病毒载体靶向的细胞特异性调节的新机制。一些RNA病毒在病毒基因组内的一系列位置中具有miRNA结合位点，包括5′和3′非翻译区。宿主细胞miRNA可以与RNA病毒基因组结合，增强基因组稳定性，抑制病毒基因组的翻译，或改变细胞内游离miRNA的水平。miRNA通过促进宿主抗病毒免疫应答的逃避、增强病毒复制或潜在地改变miRNA介导的宿主基因调控而促进病毒发病机制。RNA病毒感染可通过调节细胞特异性miRNA水平导致宿主转录组的广泛变化。
microRNAs (miRNAs) are non-coding RNAs that regulate many processes within a cell by manipulating protein levels through direct binding to mRNA and influencing translation efficiency, or mRNA abundance. Recent evidence demonstrates that miRNAs can also affect RNA virus replication and pathogenesis through direct binding to the RNA virus genome or through virus-mediated changes in the host transcriptome. Here, we review the current knowledge on the interaction between RNA viruses and cellular miRNAs. We also discuss how cell and tissue-specific expression of miRNAs can directly affect viral pathogenesis. Understanding the role of cellular miRNAs during viral infection may lead to the identification of novel mechanisms to block RNA virus replication or cell-specific regulation of viral vector targeting. Some RNA viruses possess miRNA-binding sites in a range of locations within the viral genome, including the 5′ and 3′ non-translated regions. Host cell miRNAs can bind to RNA virus genomes, enhancing genome stability, repressing translation of the viral genome, or altering free miRNA levels within the cell. miRNAs contribute to viral pathogenesis by promoting evasion of the host antiviral immune response, enhancing viral replication, or, potentially, altering miRNA-mediated host gene regulation. RNA virus infection can lead to widespread changes in the host transcriptome by modulating cell-specific miRNA levels.
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影响因子：
30.3
作者：
Barnes, Dwight;Kunitomi, Mark;Vignuzzi, Marco;Saksela, Kalle;Andino, Raul
通讯作者：
Andino, Raul
DOI：
10.1099/vir.0.044255-0
发表时间：
2012-11
期刊：
The Journal of general virology
影响因子：
--
作者：
Bakre A;Mitchell P;Coleman JK;Jones LP;Saavedra G;Teng M;Tompkins SM;Tripp RA
通讯作者：
Tripp RA
影响因子：
30.3
作者：
Aguado LC;Schmid S;Sachs D;Shim JV;Lim JK;tenOever BR
通讯作者：
tenOever BR
影响因子：
32.4
作者：
Bennasser, Y;Le, SY;Jeang, KT
通讯作者：
Jeang, KT
DOI：
10.1126/science.1215691
发表时间：
2012-04-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Djuranovic S;Nahvi A;Green R
通讯作者：
Green R