Altered metabolism and function of rat heart following chronic low level cadmium/lead feeding.
Altered metabolism and function of rat heart following chronic low level cadmium/lead feeding.
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长期低水平镉/铅喂养后大鼠心脏的代谢和功能发生改变。
DOI：
10.1016/0022-2828(80)90125-x
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发表时间：
1980
影响因子：
5
通讯作者：
PerryJr,HM
中科院分区：
文献类型：
--
作者：
Kopp,SJ;Glonek,T;Erlanger,M;Perry,EF;Bárány,M;PerryJr,HM
研究长期(15个月)、低水平(饮用水中5份/106)镉和/或铅摄入对心肌、肝脏和肾脏组织的代谢和功能(仅限心脏)的影响。染镉和/或染铅大鼠心肌峰值活动张力明显降低，组织重金属水平明显升高。用~(31)P核磁共振波谱测定，轻度高血压大鼠心肌组织中的ATP(P<；0.01)、总高能磷酸盐(P<；0.05)浓度和ATP/ADP比值(P<；0.02)均受到抑制。心肌代谢中明显的阳离子特异性变化包括甘油-3-磷胆碱(镉，对照组的25%)和二核苷酸(铅，对照组的229%)的代谢。对肝脏和肾脏组织的分析表明，镉和铅特定的生化变化与在心脏组织中观察到的变化定性相似。在铅+镉喂养的大鼠的组织中，普遍观察到相加而不是协同作用；然而，心肌磷酸肌酸(P<；0.02)和肝糖磷酸(P<；0.01)浓度受到抑制。目前化学成分尚未确定的化合物，很容易在镉和铅+镉喂养的动物的心脏和肝脏样本中检测到，但不能在铅或对照喂养的动物中检测到。
Metabolic and functional (heart only) effects of long-term (15 months), low level (5 parts/106in drinking water) cadmium and/or lead ingestion on myocardial, hepatic and renal tissues were assessed. Myocardial peak active tension was lower and tissue heavy metal levels were elevated significantly in cadmium and/or lead-exposed rats. The ATP (P< 0.01), the total high energy phosphate compound (ATP + PCr) (P< 0.05) concentrations and the ATP/ADP ratios (P< 0.02), detected by phosphorus-31 nuclear magnetic resonance spectroscopy, in myocardial tissues from mildly hypertensive rats fed cadmium, lead, and lead + cadmium were depressed. Apparent cation-specific changes in myocardial metabolism involved glycerol 3-phosphorylcholine (cadmium; 25% of control) and dinucleotide (lead; 229% of control) metabolism. Analysis of hepatic and renal tissues demonstrated cadmium-specific or lead-specific biochemical alterations which were similar qualitatively to the changes observed in cardiac tissues. Additive rather than synergistic effects were generally observed in tissues from lead + cadmium-fed rats; however, cardiac phosphocreatine (P< 0.02) and hepatic sugar phosphate (P< 0.01) concentrations were depressed. Compounds, presently of undetermined chemical composition, were readily detected in cardiac and hepatic samples from cadmium- and lead + cadmium- but not lead- or control-fed animals.
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铬、镉和铅对大鼠主动脉脂质和循环胆固醇的影响。
DOI：
10.1152/ajplegacy.1965.209.2.433
发表时间：
1965
期刊：
The American journal of physiology
影响因子：
--
作者：
H. Schroeder;J. J. Balassa
通讯作者：
J. J. Balassa
同时记录完整改良 Langendorff 大鼠心脏制剂的希氏束电图、心电图和收缩压。
影响因子：
3.8
作者：
S. J. Kopp;J. Baker;L. S. D'Agrosa;P. Hawley
通讯作者：
P. Hawley
通过磷核磁共振分析完整肌肉中磷酸盐代谢物、细胞内 pH 值和三磷酸腺苷的状态。
影响因子：
4.8
作者：
Burt Ct;T. Glonek;M. Bárány
通讯作者：
M. Bárány
分离的肌原纤维的结合核苷酸。
DOI：
10.1042/bj0510495
发表时间：
1952
期刊：
The Biochemical journal
影响因子：
--
作者：
S. Perry
通讯作者：
S. Perry
心脏收缩蛋白。
影响因子：
3.9
作者：
J. Leger;G. Berson;C. Delcaryre;C. Klotz;K. Schwartz;J. Leger;M. Stephens;B. Swynghedauw
通讯作者：
B. Swynghedauw