The Amphimedon queenslandica genome and the evolution of animal complexity.
The Amphimedon queenslandica genome and the evolution of animal complexity.
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海绵动物是一种古老的动物，在6亿多年前从其他后生动物中分化出来。在这里，我们提出的草案基因组序列的双齿蛇queenslandica，从大堡礁的demosponge，并表明它是非常相似的其他动物基因组的内容，结构和组织。通过海绵基因组测序进行的比较分析揭示了与动物起源和早期进化有关的基因组事件，包括泛后生动物转录因子、信号通路和结构基因的出现、扩增和多样化。这种多样化的基因“工具包”与所有后生动物身体计划的关键方面相关，包括细胞周期控制和生长，发育，体细胞和生殖细胞的特化，细胞粘附，先天免疫和同种异体识别。值得注意的是，许多与动物出现相关的基因也与癌症有关，癌症是由与后生动物多细胞性相关的基本过程缺陷引起的。
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse ‘toolkit’ of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.
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影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
2.9
作者：
Larroux, C;Fahey, B;Degnan, BM
通讯作者：
Degnan, BM
影响因子：
3.7
作者：
Adamska M;Degnan SM;Green KM;Adamski M;Craigie A;Larroux C;Degnan BM
通讯作者：
Degnan BM
影响因子：
7
作者：
Huang, Shengfeng;Yuan, Shaochun;Xu, Anlong
通讯作者：
Xu, Anlong
影响因子：
9.2
作者：
Larroux, Claire;Fahey, Bryony;Degnan, Bernard M.
通讯作者：
Degnan, Bernard M.