Time dependence in diffusion MRI predicts tissue outcome in ischemic stroke patients.
Time dependence in diffusion MRI predicts tissue outcome in ischemic stroke patients.
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DOI：
10.1002/mrm.28743
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发表时间：
2021-08
影响因子：
3.3
通讯作者：
Nilsson M
中科院分区：
文献类型：
--
作者：
Lampinen B;Lätt J;Wasselius J;van Westen D;Nilsson M
再灌注治疗能够有效治疗4-6小时内出现的缺血性卒中。然而，从缺血到梗死的组织进展是可变的，一些患者从治疗中获益直到24小时。需要改进的成像技术来识别这些患者。在此，假设弥散MRI的时间依赖性可预测缺血性卒中的组织结局。在卒中发作后2、9和100天，在5名非再灌注患者中采集了多个弥散时间的弥散MRI数据。得出了“峰度变化率”（k）、平均峰度、ADC和分数各向异性的图。ADC映射定义的病变、外观正常的组织和到第100天将梗死或保持存活的病变组织。比较（1）病变和外观正常组织之间的扩散参数，以及（2）将梗死或保持活力的病变组织之间的扩散参数。在第2天（P = 0.001）和第9天（P = 0.023），在卒中病灶内观察到k值为正值，表明弥散交换。在第100天，高ADC值表明梗死占病变体积的50 ± 20%。第2天（P = .026）和第9天（P = .046）的高k值、第2天的低平均峰度值（P = .043）和第9天的低各向异性分数值（P = .029）可预测组织梗死，但低ADC值不能预测。弥散时间依赖性比ADC更准确地预测缺血性卒中的组织结局，并可能有助于预测再灌注获益。
Reperfusion therapy enables effective treatment of ischemic stroke presenting within 4–6 hours. However, tissue progression from ischemia to infarction is variable, and some patients benefit from treatment up until 24 hours. Improved imaging techniques are needed to identify these patients. Here, it was hypothesized that time dependence in diffusion MRI may predict tissue outcome in ischemic stroke. Diffusion MRI data were acquired with multiple diffusion times in five non-reperfused patients at 2, 9, and 100 days after stroke onset. Maps of “rate of kurtosis change” (k), mean kurtosis, ADC, and fractional anisotropy were derived. The ADC maps defined lesions, normal-appearing tissue, and the lesion tissue that would either be infarcted or remain viable by day 100. Diffusion parameters were compared (1) between lesions and normal-appearing tissue, and (2) between lesion tissue that would be infarcted or remain viable. Positive values of k were observed within stroke lesions on day 2 (P = .001) and on day 9 (P = .023), indicating diffusional exchange. On day 100, high ADC values indicated infarction of 50 ± 20% of the lesion volumes. Tissue infarction was predicted by high k values both on day 2 (P = .026) and on day 9 (P = .046), by low mean kurtosis values on day 2 (P = .043), and by low fractional anisotropy values on day 9 (P = .029), but not by low ADC values. Diffusion time dependence predicted tissue outcome in ischemic stroke more accurately than the ADC, and may be useful for predicting reperfusion benefit.
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影响因子：
8.3
作者：
Baron, Corey Allan;Kate, Mahesh;Beaulieu, Christian
通讯作者：
Beaulieu, Christian
DOI：
10.1016/s1474-4422(12)70203-x
发表时间：
2012-10
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Lansberg MG;Straka M;Kemp S;Mlynash M;Wechsler LR;Jovin TG;Wilder MJ;Lutsep HL;Czartoski TJ;Bernstein RA;Chang CW;Warach S;Fazekas F;Inoue M;Tipirneni A;Hamilton SA;Zaharchuk G;Marks MP;Bammer R;Albers GW;DEFUSE 2 study investigators
通讯作者：
DEFUSE 2 study investigators
影响因子：
168.9
作者：
Emberson, Jonathan;Lees, Kennedy R.;Lyden, Patrick;Blackwell, Lisa;Albers, Gregory;Bluhmki, Erich;Brott, Thomas;Cohen, Geoff;Davis, Stephen;Donnan, Geoffrey;Grotta, James;Howard, George;Kaste, Markku;Koga, Masatoshi;von Kummer, Ruediger;Lansberg, Maarten;Lindley, Richard I.;Murray, Gordon;Olivot, Jean Marc;Parsons, Mark;Tilley, Barbara;Toni, Danilo;Toyoda, Kazunori;Wahlgren, Nils;Wardlaw, Joanna;Whiteley, William;del Zoppo, Gregory J.;Baigent, Colin;Sandercock, Peter;Hacke, Werner
通讯作者：
Hacke, Werner
影响因子：
3.3
作者：
Lampinen B;Szczepankiewicz F;van Westen D;Englund E;C Sundgren P;Lätt J;Ståhlberg F;Nilsson M
通讯作者：
Nilsson M
影响因子：
8.3
作者：
Cheung JS;Wang E;Lo EH;Sun PZ
通讯作者：
Sun PZ