High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.
High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.
复制标题
高剪切应力通过血管生成诱导动脉粥样硬化易损斑块形成
DOI：
10.1093/rb/rbw021
复制
发表时间：
2016-12
影响因子：
6.7
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Wang Y;Qiu J;Luo S;Xie X;Zheng Y;Zhang K;Ye Z;Liu W;Gregersen H;Wang G
动脉粥样硬化斑块破裂引起血栓形成是急性冠状动脉综合征和缺血性中风的主要原因。抑制血栓形成是开发血管内支架和血管移植物等生物医用材料的重要任务之一。剪切应力（SS）影响动脉粥样硬化的形成和发展。目前的审查重点是在高剪切应力（HSS）区域，这局限于近端区域的斑块侵入管腔中观察到的易损斑块。HSS区的血管发生向外重塑，以实现血管代偿，而血管生成是HSS诱导动脉粥样硬化易损斑块形成的关键因素。这些结果极大地挑战了已建立的信念，即低剪切应力是重要的扩张性重塑，这提供了一个新的视角，防止稳定斑块的转变为高风险的动脉粥样硬化病变。
Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes. Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts. Shear stress (SS) influences the formation and development of atherosclerosis. The current review focuses on the vulnerable plaques observed in the high shear stress (HSS) regions, which localizes at the proximal region of the plaque intruding into the lumen. The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation. These results greatly challenge the established belief that low shear stress is important for expansive remodelling, which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions.
影响因子：
2.5
作者：
Zheng, Jie;Abendschein, Dana R.;Okamoto, Ruth J.;Yang, Deshan;McCommis, Kyle S.;Misselwitz, Bernd;Gropler, Robert J.;Tang, Dalin
通讯作者：
Tang, Dalin