MRI-based biomechanical imaging: initial study on early plaque progression and vessel remodeling.
MRI-based biomechanical imaging: initial study on early plaque progression and vessel remodeling.
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DOI：
10.1016/j.mri.2009.05.032
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发表时间：
2009-12
影响因子：
2.5
通讯作者：
Tang, Dalin
中科院分区：
文献类型：
--
作者：
Zheng, Jie;Abendschein, Dana R.;Okamoto, Ruth J.;Yang, Deshan;McCommis, Kyle S.;Misselwitz, Bernd;Gropler, Robert J.;Tang, Dalin
该研究的目的是开发一种基于无创磁共振成像（MRI）的生物力学成像技术，以使用3D流体-结构相互作用（FSI）模型来解决体内动脉粥样硬化进展和消退的生物力学途径。在猪的早期斑块模型中进行了初步的体内研究，该模型对左颈动脉进行了球囊过度拉伸损伤。在猪维持高胆固醇（进展）或正常饮食（消退）的同时，注射斑块靶向造影剂Gadofluorine M，进行连续MRI扫描。在研究结束时，解剖颈动脉段的样本，并进行专门的机械测试，以确定其材料特性。采用三维流固耦合计算模型计算结构应力应变分布。斑块结构类似于早期斑块，内膜增厚。较低的最大血流切应力与进展过程中斑块体积的增长相关，但与消退过程无关。相反，最大主结构应力/应变（应力-P1和应变-P1）显示出与消退期间斑块尺寸的变化强烈相关，但在进展期间适度相关。这种基于MRI的生物力学成像方法可用于无创动态评估局部血流动力学对体内动脉粥样硬化斑块发展的影响。
The goal of the study is to develop a noninvasive magnetic resonance imaging (MRI)-based biomechanical imaging technique to address biomechanical pathways of atherosclerotic progression and regression in vivo using a 3D fluid-structure interaction (FSI) model. Initial in vivo study was carried out in an early plaque model in pigs that underwent balloon-overstretch injury to the left carotid arteries. Consecutive MRI scans were performed while the pigs were maintained on high cholesterol (progression) or normal chow (regression), with an injection of a plaque-targeted contrast agent, Gadofluorine M. At the end of study, the specimens of carotid arterial segments were dissected and underwent dedicated mechanical testing to determine their material properties. 3D FSI computational model was applied to calculate structure stress and strain distribution. The plaque structure resembles early plaque with thickened intima. Lower maximal flow shear stress correlates with the growth of plaque volume during progression, but not during regression. In contrast, maximal principle structure stress/stain (stress-P1 and strain-P1) were shown to correlate strongly with the change in the plaque dimension during regression, but moderately during progression. This MRI-based biomechanical imaging method may allow for noninvasive dynamic assessment of local hemodynamic forces on the development of atherosclerotic plaques in vivo.
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作者：
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通讯作者：
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