Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism.
Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism.
复制标题
DOI：
10.1016/j.thromres.2022.06.008
复制
发表时间：
2022-08
影响因子：
7.5
通讯作者：
Reynolds, Kristi
中科院分区：
文献类型：
--
作者：
Fang, Margaret C.;Go, Alan S.;Prasad, Priya A.;Zhou, Hui X.;Parks, Anna L.;Fan, Dongjie;Portugal, Cecilia;Sung, Sue Hee;Reynolds, Kristi
关键词：
静脉血栓栓塞（VTE）通常使用口服抗凝剂治疗，包括华法林或直接口服抗凝剂（DOAC）。尽管DOAC与良好的治疗满意度相关，但很少有研究评估DOAC和华法林使用者之间的生活质量是否存在差异。我们邀请了在加利福尼亚州的两个综合医疗保健提供系统中注册的成年人，并在2015年1月1日至2018年6月30日期间有VTE病史，以完成对他们使用抗凝剂经验的调查。使用兰德36项简明健康调查表（SF-36）评估健康相关生活质量（QOL），该调查表以2个一般组分评分（身体和精神）测量QOL。我们使用多变量线性回归来比较DOAC使用者和华法林使用者之间的平均QOL分量评分，并根据患者和临床特征进行调整。总体而言，2，230例服用抗凝剂的患者（43.1%为女性，31.8% >75岁）回答了至少1个SF-36问题，975例服用DOAC，1255例服用华法林。调整患者水平因素后，DOAC和华法林使用者之间的身体成分评分（39.2 v38.3，p=0.24）或心理成分评分（48.5 v49.0，p=0.42）无显著差异。有VTE病史的DOAC和华法林使用者的健康相关QOL无显著差异。
Venous thromboembolism (VTE) is commonly treated with oral anticoagulants, including warfarin or direct oral anticoagulants (DOACs). Although DOACs are associated with favorable treatment satisfaction, few studies have assessed whether quality of life differs between DOAC and warfarin users. We invited adults enrolled in two California-based integrated health care delivery systems and with a history of VTE between January 1, 2015 and June 30, 2018 to complete a survey on their experience with anticoagulants. Health-related quality of life (QOL) was assessed using the RAND 36-item Short Form Health Survey (SF-36), which measures QOL in 2 general component scores (physical and mental). We used multivariable linear regression to compare mean QOL component scores between DOAC-users and warfarin-users, adjusting for patient and clinical characteristics. Overall, 2,230 patients (43.1% women and 31.8% >75 years of age) taking anticoagulants answered at least 1 question on the SF-36, 975 taking DOACs and 1255 taking warfarin. After adjustment for patient-level factors, there were no significant differences in either physical component scores (39.2 v 38.3, p=0.24) or mental component scores (48.5 v 49.0, p=0.42) between DOAC and warfarin users. Health-related QOL did not significantly differ between DOAC and warfarin users with a history of VTE.
登录
查看更多内容
影响因子：
2.2
作者：
Ng, Diana Leh-Ching;Gan, Gin-Gin;Bee, Ping-Chong
通讯作者：
Bee, Ping-Chong
影响因子：
--
作者：
LANCASTER, TR;SINGER, DE;KISTLER, JP
通讯作者：
KISTLER, JP
影响因子：
3.5
作者：
Monz, B. U.;Connolly, S. J.;Pooley, J.
通讯作者：
Pooley, J.
影响因子：
37.8
作者：
White, RH
通讯作者：
White, RH
影响因子：
7.5
作者：
Miert, Jasper H. A. van;Kooistra, Hilde A. M.;Meijer, Karina
通讯作者：
Meijer, Karina