Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice.
Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice.
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DOI：
10.1371/journal.pone.0060722
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tarnopolsky M
中科院分区：
文献类型：
--
作者：
Abadi A;Crane JD;Ogborn D;Hettinga B;Akhtar M;Stokl A;Macneil L;Safdar A;Tarnopolsky M
抗氧化剂补充剂被普通大众广泛消费；然而，它们对运动表现的影响是有争议的。本研究的目的是研究抗氧化剂鸡尾酒（α-硫辛酸、维生素E和辅酶Q10）对小鼠运动表现、肌肉功能和训练适应性的影响。将C57Bl/J6小鼠分别给予抗氧化剂补充或安慰剂对照饮食（n = 36/组），分为训练组（8周跑步）（n = 12/组）和未训练组（n = 24/组）。补充抗氧化剂对训练小鼠的跑步表现没有影响，也没有影响训练适应性；然而，未经训练的雌性小鼠接受抗氧化剂的表现明显优于安慰剂对照组小鼠（p≤0.05）。此外，与安慰剂对照组相比，补充抗氧化剂的雌性（未经训练）在新鲜切除的肌肉纤维（股四头肌）中表现出更高的呼吸能力（p≤0.05），肌肉蛋白的氧化损伤减少（p≤0.05），线粒体蛋白的表达增加（p≤0.05）。这些变化归因于添加抗氧化剂通过激活amp活化的蛋白激酶（AMPK）增加增殖因子激活受体γ辅助激活因子1α (PGC-1α)的表达（p≤0.05）（p≤0.05）。总的来说，这些结果表明这种抗氧化剂补充剂具有性别特异性效应；增强未训练女性的表现和线粒体功能，但不减弱训练适应性。
Antioxidant supplements are widely consumed by the general public; however, their effects of on exercise performance are controversial. The aim of this study was to examine the effects of an antioxidant cocktail (α-lipoic acid, vitamin E and coenzyme Q10) on exercise performance, muscle function and training adaptations in mice. C57Bl/J6 mice were placed on antioxidant supplement or placebo-control diets (n = 36/group) and divided into trained (8 wks treadmill running) (n = 12/group) and untrained groups (n = 24/group). Antioxidant supplementation had no effect on the running performance of trained mice nor did it affect training adaptations; however, untrained female mice that received antioxidants performed significantly better than placebo-control mice (p ≤ 0.05). Furthermore, antioxidant-supplemented females (untrained) showed elevated respiratory capacity in freshly excised muscle fibers (quadriceps femoris) (p ≤ 0.05), reduced oxidative damage to muscle proteins (p ≤ 0.05), and increased expression of mitochondrial proteins (p ≤ 0.05) compared to placebo-controls. These changes were attributed to increased expression of proliferator-activated receptor gamma coactivator 1α (PGC-1α) (p ≤ 0.05) via activation of AMP-activated protein kinase (AMPK) (p ≤ 0.05) by antioxidant supplementation. Overall, these results indicate that this antioxidant supplement exerts gender specific effects; augmenting performance and mitochondrial function in untrained females, but does not attenuate training adaptations.
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影响因子：
2.9
作者：
Knab, Amy M.;Bowen, Robert S.;Moore-Harrison, Trudy;Hamilton, Alicia Trynor;Turner, Michael J.;Lightfoot, J. Timothy
通讯作者：
Lightfoot, J. Timothy
DOI：
10.1152/ajpendo.00187.2009
发表时间：
2009-08-01
影响因子：
5.1
作者：
Comitato, Raffaella;Nesaretnam, Kalanithi;Virgili, Fabio
通讯作者：
Virgili, Fabio
DOI：
10.1016/j.bbrc.2005.05.035
发表时间：
2005-07-08
影响因子：
3.1
作者：
Lee, WJ;Song, KH;Park, JY
通讯作者：
Park, JY
影响因子：
3
作者：
Bailey, David M.;Williams, Clyde;Hurst, Tina L.
通讯作者：
Hurst, Tina L.
DOI：
10.1073/pnas.0705070104
发表时间：
2007-07-17
影响因子：
11.1
作者：
Jaeger, Sibylle;Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.