Familial rates of affective disorder. A report from the National Institute of Mental Health Collaborative Study.
Familial rates of affective disorder. A report from the National Institute of Mental Health Collaborative Study.
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情感障碍的家族发病率。
作者：
N. Andreasen;J. Rice;J. Endicott;W. Coryell;W. Grove;T. Reich
我们调查了在国家精神卫生研究所抑郁症心理生物学合作研究的五个中心研究的955名先证者中，情感障碍和相关疾病的家族率：波士顿、芝加哥、爱荷华市、纽约和圣路易斯。这些先证者中有616人进入了家庭研究，3423人的一级亲属接受了评估。先证者分为5组：分裂情感双相(n=37)、分裂情感抑郁(n=18)、双相I(n=151)、双相II(n=76)和单相(n=330)。双相I型先证者亲属的双相I型患病率高于单相I型先证者，但单相I型先证者的单相患病率并不高于双相型I型先证者。分裂情感性精神障碍先证者抑郁亚型亲属的精神分裂症发生率高于分裂情感性双相情感障碍先证者，提示双相分裂情感性精神障碍可能更接近于单纯情感性精神障碍，而分裂情感性抑郁可能更接近精神分裂症。在双相II型先证者的亲属中也观察到双相II型疾病的增加。总体而言，这些数据支持了被广泛接受的双相情感障碍和单相情感障碍之间的区别。
We examined familial rates of affective disorder and related illness in a cohort of 955 probands studied at five centers in the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression: Boston, Chicago, Iowa City, New York, and St. Louis. Six hundred sixteen of these probands were entered into a family study, and 3423 of their first-degree relatives were evaluated. The probands were divided into five diagnostic groups: schizoaffective-bipolar (n = 37), schizoaffective-depressed (n = 18), bipolar I (n = 151), bipolar II (n = 76), and unipolar (n = 330). The relatives of bipolar I probands had a higher rate of bipolar I illness than the relatives of unipolar probands, but the relatives of unipolar probands did not have a higher rate of unipolar illness than the relatives of bipolar I probands. The relatives of probands with schizoaffective disorder, depressed subtype, had a higher rate of schizophrenia than the relatives of schizoaffective-bipolar probands, suggesting that bipolar schizoaffective disorder may be closer to pure affective disorder while schizoaffective depression may be closer to schizophrenia. An increase in bipolar II illness was also observed in the relatives of bipolar II probands. Overall, these data support the widely accepted distinction between bipolar and unipolar affective disorders.
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影响因子：
--
作者：
Andreasen,NC;Rice,J;Endicott,J;Reich,T;Coryell,W
通讯作者：
Coryell,W
在多中心设计中评估精神疾病患者的重测可靠性。
影响因子：
4.8
作者：
Keller,MB;Lavori,PW;Andreasen,NC;Grove,WM;Shapiro,RW;Scheftner,W;McDonald-Scott,P
通讯作者：
McDonald-Scott,P
影响因子：
--
作者：
M. Weissman;K. Kidd;B. Prusoff
通讯作者：
M. Weissman;K. Kidd;B. Prusoff
情感障碍患者亲属中重度抑郁症发病率的出生队列趋势。
影响因子：
--
作者：
Klerman,GL;Lavori,PW;Rice,J;Reich,T;Endicott,J;Andreasen,NC;Keller,MB;Hirschfield,RM
通讯作者：
Hirschfield,RM
影响因子：
--
作者：
Grove,WM;Andreasen,NC;McDonald-Scott,P;Keller,MB;Shapiro,RW
通讯作者：
Shapiro,RW