Prevalence and change in psychiatric disorders among perinatally HIV-infected and HIV-exposed youth.
Prevalence and change in psychiatric disorders among perinatally HIV-infected and HIV-exposed youth.
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DOI：
10.1080/09540121.2012.668174
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发表时间：
2012
期刊：
影响因子：
1.7
通讯作者：
Abrams EJ
中科院分区：
文献类型：
--
作者：
Mellins CA;Elkington KS;Leu CS;Santamaria EK;Dolezal C;Wiznia A;Bamji M;Mckay MM;Abrams EJ
随着资源丰富国家的儿科艾滋病毒流行病演变为青少年流行病，有实质性的研究需要阐明围产期艾滋病毒感染（PHIV+）的青年，因为他们过渡到青春期的心理健康需求。本文通过比较围产期HIV感染者（PHIV+）和围产期HIV暴露但未感染（PHIV−）青年中精神疾病和物质使用障碍（SUD）的变化，探讨围产期HIV感染在影响心理健康方面的作用。参与者从纽约市的四个医疗中心招募。在基线和18个月随访时，对166名PHIV+和114名PHIV-青年（49%为男性，基线时年龄为9-16岁）进行了个体访谈。青少年精神障碍的评估使用的儿童诊断访谈计划（DISC-IV）的照顾者和青年版本。超过三分之二的参与者在基线或随访时符合至少一种精神疾病的标准，几乎没有组间差异。在PHIV+青年中，任何精神疾病的患病率都显着下降，特别是随着时间的推移，焦虑症的患病率也显着下降，而PHIV-青年中任何精神疾病的患病率保持不变，情绪障碍增加。两组的SUD发生率均较低，随访时略有增加。PHIV+青少年在随访时报告更多地使用心理健康服务。在任一时间点，CD 4计数和HIV RNA病毒载量与疾病的存在或不存在无关。总之，即使与其他弱势群体相比，在PHIV+和PHIV−青年中，精神障碍的发病率也很高，这表明围产期艾滋病毒感染以外的因素可能是心理健康的重要决定因素。在观察期内，PHIV+青年更有可能改善。这些数据强调了对PHIV+和PHIV−青年进行心理健康干预的迫切需要。
As the pediatric HIV epidemic in resource-rich countries evolves into an adolescent epidemic, there is a substantive need for studies elucidating mental health needs of perinatally HIV-infected (PHIV+) youth as they transition through adolescence. This article examines the role of perinatal HIV infection in influencing mental health by comparing changes in psychiatric disorders and substance use disorders (SUD) in perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected (PHIV−) youth over time. Participants were recruited from four medical centers in New York City. Individual interviews were administered at baseline and 18-month follow-up to 166 PHIV+ and 114 PHIV-youth (49% male, age 9–16 at baseline). Youth psychiatric disorder was assessed using the caregiver and youth versions of the Diagnostic Interview Schedule for Children (DISC-IV). Over two-thirds of participants met criteria for at least one psychiatric disorder at either baseline or follow-up, with few group differences. Among PHIV+ youth, there was a significant decrease in the prevalence of any psychiatric disorder, as well as anxiety disorders specifically over time, while prevalence of any psychiatric disorder among PHIV− youth remained the same and mood disorders increased. Rates of SUD were low in both groups, increasing slightly by follow-up. PHIV+ youth reported more use of mental health services at follow-up. CD4 count and HIV RNA Viral Load were not associated with presence or absence of disorder at either time point. In conclusion, among PHIV+ and PHIV− youth, rates of psychiatric disorder were high, even compared to other vulnerable populations, suggesting that factors other than perinatal HIV infection may be important determinants of mental health. PHIV+ youth were more likely to improve over the observation period. The data underscore the critical need for mental health interventions for both PHIV+ and PHIV− youth.
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影响因子：
8
作者：
Nozyce, ML;Lee, SS;Pelton, S
通讯作者：
Pelton, S
影响因子：
6.9
作者：
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通讯作者：
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影响因子：
5.9
作者：
Kendall, PC;FlannerySchroeder, E;Warman, M
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影响因子：
1.7
作者：
Malee KM;Tassiopoulos K;Huo Y;Siberry G;Williams PL;Hazra R;Smith RA;Allison SM;Garvie PA;Kammerer B;Kapetanovic S;Nichols S;Van Dyke R;Seage GR 3rd;Mellins CA;Pediatric HIV/AIDS Cohort Study Team
通讯作者：
Pediatric HIV/AIDS Cohort Study Team
DOI：
10.1016/j.jaac.2010.05.017
发表时间：
2010-10
影响因子：
13.3
作者：
Merikangas KR;He JP;Burstein M;Swanson SA;Avenevoli S;Cui L;Benjet C;Georgiades K;Swendsen J
通讯作者：
Swendsen J