One march, many paths: Insights into allergic march trajectories.
One march, many paths: Insights into allergic march trajectories.
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DOI：
10.1016/j.anai.2021.04.036
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Hill DA
中科院分区：
文献类型：
--
作者：
Gabryszewski SJ;Hill DA
经典的变应性行军模型假定，特应性在婴儿期开始出现特应性皮炎，并在一部分个体中发展为哮喘和变应性鼻炎。变应性疾病的日益普遍和严重性促使人们重新对完善这一模型产生了兴趣。本文概述了过敏行进轨迹（个体特应性发展的不同路径）存在的流行病学证据，回顾了遗传、环境和疾病内型在决定轨迹结果中所发挥的作用，并讨论了轨迹模型的临床实用性。PubMed检索无日期限制的英语文章和综述，涉及过敏性行进轨迹和疾病内在型的流行病学、遗传学和免疫学机制。选择研究和评论是基于其高质量和与审查主题的直接相关性。该领域的最新研究表明，IgE介导的食物过敏和嗜酸性食管炎是过敏性进展的组成部分。此外，该领域承认个体发展的过敏表现的数量和顺序存在可变性。这些过敏性行进路径或轨迹受到遗传，环境和心理社会因素的影响，这些因素尚未完全了解。持续阐明过敏性行军轨迹的景观和起源将为个性化过敏性疾病的预防，诊断和治疗提供信息。
The classical allergic march model posits that atopy begins in infancy with atopic dermatitis and progresses to asthma and allergic rhinitis in a subset of individuals. The growing prevalence and severity of allergic diseases has prompted renewed interest in refining this model. This review outlines epidemiologic evidence for the existence of allergic march trajectories (distinct paths of atopy development in individuals), reviews the roles that genetics, environment, and disease endotypes play in determining trajectory outcomes, and discusses the clinical utility of the trajectory model. PubMed search of English-language articles and reviews without date limits pertaining to the epidemiology, genetics, and immunologic mechanisms of allergic march trajectories and disease endotypes. Studies and reviews were selected based on their high quality and direct relevance to the review topic. Recent work in the field has shown that IgE-mediated food allergy and eosinophilic esophagitis are components of the allergic march. Further, the field is acknowledging that variability exists in the number and sequence of allergic manifestations that individuals develop. These allergic march pathways, or trajectories, are influenced by genetic, environmental, and psychosocial factors that are incompletely understood. Continued elucidation of the landscape and origins of allergic march trajectories will inform efforts to personalize allergic disease prevention, diagnosis, and treatment.
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影响因子：
2.4
作者：
Hill DA;Grundmeier RW;Ram G;Spergel JM
通讯作者：
Spergel JM
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
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Pipper, Christian Bressen
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5.1
作者：
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通讯作者：
Momas, Isabelle
影响因子：
5.9
作者：
Gonzalez-Cervera, Jesus;Arias, Angel;Lucendo, Alfredo J.
通讯作者：
Lucendo, Alfredo J.
影响因子：
15.8
作者：
Belgrave DC;Granell R;Simpson A;Guiver J;Bishop C;Buchan I;Henderson AJ;Custovic A
通讯作者：
Custovic A