Role of rho kinase in the functional and dysfunctional tonic smooth muscles.
Role of rho kinase in the functional and dysfunctional tonic smooth muscles.
复制标题
DOI：
10.1016/j.tips.2011.03.005
复制
发表时间：
2011-07
影响因子：
13.8
通讯作者：
Rattan S
中科院分区：
文献类型：
--
作者：
de Godoy MA;Rattan S
紧张性平滑肌在胃肠道和心血管系统衰弱性疾病的病理生理学中起关键作用。张力性平滑肌与时相性平滑肌的不同之处在于自发形成肌源性张力的能力。这种能力主要归因于特定神经体液物质的局部产生，所述神经体液物质可通过与Ras同源基因家族成员A（RhoA）/Rho相关的卷曲螺旋蛋白激酶2（ROCK II）途径相关的信号转导事件与钙致敏作用结合。在这篇文章中，我们讨论了紧张性平滑肌的肌源性的分子途径，特别是蛋白激酶C与RhoA/ROCK II通路的基础张力，病理生理学的起源的贡献，以及某些胃肠道和心血管疾病的新的治疗方法。新出现的证据表明，操纵RhoA/ROCK II活性通过抑制剂或沉默的RNA接口技术可能代表一种新的治疗方法，用于各种胃肠道和心血管疾病。
Tonic smooth muscles play pivotal roles in the pathophysiology of debilitating diseases of the gastrointestinal and cardiovascular systems. Tonic smooth muscles differ from phasic smooth muscles in the ability to spontaneously develop myogenic tone. This ability has been primarily attributed to the local production of specific neurohumoral substances that may work in conjunction with calcium sensitization via signal transduction events associated with the Ras homolog gene family, member A (RhoA)/Rho-associated, coiled-coil containing protein kinase 2 (ROCK II) pathways. In this article, we discuss the molecular pathways involved in the myogenic properties of tonic smooth muscles, particularly the contribution of protein kinase C versus the RhoA/ROCK II pathway in the genesis of basal tone, pathophysiology, and novel therapeutic approaches for certain gastrointestinal and cardiovascular diseases. Emerging evidence suggests that manipulation of RhoA/ROCK II activity through inhibitors or silencing of RNA interface techniques could represent a new therapeutic approach for various gastrointestinal and cardiovascular diseases.
登录
查看更多内容
影响因子：
7.4
作者：
Dong, Ming;Yan, Bryan P.;Liao, James K.;Lam, Yat-Yin;Yip, Gabriel W. K.;Yu, Cheuk-Man
通讯作者：
Yu, Cheuk-Man
影响因子：
29.4
作者：
Casselbrant, Anna;Edebo, Anders;Fandriks, Lars
通讯作者：
Fandriks, Lars
影响因子：
29.4
作者：
De Godoy, MAF;Dunn, S;Rattan, S
通讯作者：
Rattan, S
影响因子：
11.2
作者：
Chang, Yu-Wen E.;Marlin, Jerry W.;Jakobi, Rolf
通讯作者：
Jakobi, Rolf
影响因子：
37.8
作者：
Bolz, SS;Vogel, L;Pohl, U
通讯作者：
Pohl, U